Articles

Osteochondral tissue engineering using a biphasic collagen/GAG scaffold containing rhFGF18 or BMP-7 in an ovine model

The aim of this study was to investigate the effect of combining rhFGF18 or BMP-7 with a biphasic collagen/GAG osteochondral scaffold (Chondromimetic) on the repair of osteochondral defects in sheep.

Authors: Alan Getgood, Frances Henson, Carrie Skelton, Roger Brooks, Hans Guehring, Lisa A Fortier and Neil Rushton

Role of mesenchymal stem cells in meniscal repair

Meniscus integrity is the key for joint health of the knee. Therefore, the main goal of every meniscus treatment should be the maintenance of as much meniscus tissue as possible.

Authors: Peter Angele, Richard Kujat, Matthias Koch and Johannes Zellner

Polymerase Chain Reaction molecular diagnostic technology for monitoring chronic osteomyelitis

Osteomyelitis is a devastating condition whose treatment relies on the detection of bacteria. The current standard of microbiology culture may not be adequate. Molecular biology based diagnostic procedures for...

Authors: Brian D Mariani, Daniel S Martin, Antonia F Chen, Haruyo Yagi, Sheldon S Lin and Rocky S Tuan

Clinical results of multilayered biomaterials for osteochondral regeneration

Several techniques have been used during the years to treat chondral and osteochondral lesions. Among them, the emerging trend in the field of osteochondral regeneration is to treat the entire osteochondral un...

Authors: Elizaveta Kon, Giuseppe Filardo, Francesco Perdisa, Giulia Venieri and Maurilio Marcacci

The role of aggrecan in normal and osteoarthritic cartilage

Aggrecan is a large proteoglycan bearing numerous chondroitin sulfate and keratan sulfate chains that endow articular cartilage with its ability to withstand compressive loads. It is present in the extracellul...

Authors: Peter J Roughley and John S Mort

Induction of bone formation in abdominal implants constituted by collagen sponges embedded with plant-based human transforming growth factor family proteins in ectopic dog model

Trauma, osteomyelitis, bone tumour resections and congenital deformities are the main causes of bone deficiency in which autologous graft is the preferred treatment, but usually the bone supplies are limited.

Authors: Juan Carlos Jacinto-Tinajero, Daniel Ascencio, Brenda Marquina, Jorge Barrios-Payán, Maria Concepcion Gutierrez, Miguel Gomez Lim and Rogelio Hernández Pando

A new basic science journal for ESSKA

Authors: Jon Karlsson, João Espregueira-Mendes and C Niek van Dijk

Measurements of bone tunnel size in anterior cruciate ligament reconstruction: 2D versus 3D computed tomography model

Revision anterior cruciate ligament (ACL) reconstruction requires a precise evaluation of previous tunnel locations and diameters. Enlargement of the tunnels, despite not usually affecting primary reconstructi...

Authors: Bernardo Crespo, Cathrine Aga, Katharine J Wilson, Shannon M Pomeroy, Robert F LaPrade, Lars Engebretsen and Coen A Wijdicks

Strength of the porcine proximal femoral epiphyseal plate: the effect of different loading directions and the role of the perichondrial fibrocartilaginous complex and epiphyseal tubercle – an experimental biomechanical study

The high loads on adolescent athletes’ musculoskeletal system are known to cause morphological and degenerative changes in bone, intervertebral discs and joints. It has been suggested that the cam deformity of...

Authors: Páll Sigurgeir Jónasson, Lars Ekström, Anna Swärd, Mikael Sansone, Mattias Ahldén, Jón Karlsson and Adad Baranto

Digital image correlation as a tool for three-dimensional strain analysis in human tendon tissue

Determining the mechanical behaviour of tendon and ligamentous tissue remains challenging, as it is anisotropic, non-linear and inhomogeneous in nature.

Authors: Thomas Luyckx, Matthias Verstraete, Karel De Roo, Wim De Waele, Johan Bellemans and Jan Victor

Biomechanical testing of distal femur osteotomy plate fixation techniques: the role of simulated physiological loading

Implants for fracture and/or osteotomy fixation are often tested according to basic mechanical test models such as open gap tests or 4-point-bending tests. These may be suitable to test and compare different i...

Authors: Justus-Martijn Brinkman, Christof Hurschler, Jens Agneskirchner, Philip Lobenhoffer, René M Castelein and Ronald J van Heerwaarden

Biomechanical evaluation of a biomimetic spinal construct

Laboratory spinal biomechanical tests using human cadaveric or animal spines have limitations in terms of disease transmission, high sample variability, decay and fatigue during extended testing protocols. The...

Authors: Tian Wang, Jonathon R Ball, Mattew H Pelletier and William R Walsh

Translating orthopaedic basic science into clinical relevance

In orthopaedic and trauma surgery, the rapid evolution of biomedical research has fundamentally changed the perception of the musculoskeletal system. Here, the rigor of basic science and the art of musculoskel...

Authors: Henning Madry