Articles

Recent developments in evaluation and treatment of lateral patellar instability

Recent years have been characterized by an ongoing increase in knowledge about the different conditions associated with lateral patellar instability. This increase in knowledge provides differentiated approach...

Authors: Alexander Zimmerer, Christian Sobau and Peter Balcarek

Scaffold-free tissue engineering for injured joint surface restoration

Articular cartilage does not heal spontaneously due to its limited healing capacity, and thus effective treatments for cartilage injuries has remained challenging. Since the first report by Brittberg et al. in...

Authors: Kazunori Shimomura, Wataru Ando, Hiromichi Fujie, David A. Hart, Hideki Yoshikawa and Norimasa Nakamura

Boosting tendon repair: interplay of cells, growth factors and scaffold-free and gel-based carriers

Tendons are dense connective tissues and critical components for the integrity and function of the musculoskeletal system. Tendons connect bone to muscle and transmit forces on which locomotion entirely depend...

Authors: Zexing Yan, Heyong Yin, Michael Nerlich, Christian G. Pfeifer and Denitsa Docheva

Novel flat and wide meniscal repair material improves the ultimate load of knot breakage in a porcine trans-capsular meniscal repair model

In the meniscal repair procedures, a high ultimate load capacity and low cyclic creep at the repair site are favorable and lead to good biological incorporation of the tear site after surgery. Previous biomech...

Authors: Hiroyuki Yokoi, Tatsuo Mae, Ryo Iuchi, Yasuhiro Take, Yuta Tachibana, Kazunori Shimomura, Tomoki Ohori, Konsei Shino, Hideki Yoshikawa and Ken Nakata

Intraarticular arthrofibrosis of the knee alters patellofemoral contact biomechanics

Arthrofibrosis in the suprapatellar pouch and anterior interval can develop after knee injury or surgery, resulting in anterior knee pain. These adhesions have not been biomechanically characterized.

Authors: Jacob D. Mikula, Erik L. Slette, Kimi D. Dahl, Scott R. Montgomery, Grant J. Dornan, Luke O’Brien, Travis Lee Turnbull and Thomas R. Hackett

Static and fatigue strength of a novel anatomically contoured implant compared to five current open-wedge high tibial osteotomy plates

The purpose of the present study was to compare the mechanical static and fatigue strength of the size 2 osteotomy plate “Activmotion” with the following five other common implants for the treatment of medial ...

Authors: Arnaud Diffo Kaze, Stefan Maas, James Belsey, Alexander Hoffmann and Dietrich Pape

The use of lumbar epidural injection of platelet lysate for treatment of radicular pain

Epidural steroid injections (ESI) are the most common pain management procedure performed in the US, however evidence of efficacy is limited. In addition, there is early evidence that the high dose of corticos...

Authors: Christopher Centeno, Jason Markle, Ehren Dodson, Ian Stemper, Matthew Hyzy, Christopher Williams and Michael Freeman

Glucosamine reduces the inhibition of proteoglycan metabolism caused by local anaesthetic solution in human articular cartilage: an in vitro study

We assessed whether local anaesthetics caused inhibition of proteoglycan metabolism in human articular cartilage and whether the addition of Glucosamine sulphate could prevent or allow recovery from this adver...

Authors: Abhinav Gulihar, Shalin Shaunak, Pinelopi Linardatou Novak, Parthiban Vinayakam, Baljinder Dhinsa and Grahame Taylor

Tacrolimus as an adjunct to autologous minced muscle grafts for the repair of a volumetric muscle loss injury

Volumetric muscle loss (VML) following extremity orthopaedic trauma or surgery results in chronic functional deficits and disability. A current translational approach to address the devastating functional limi...

Authors: Benjamin T. Corona, Jessica C. Rivera, Joseph C. Wenke and Sarah M. Greising

Determination of knee cartilage volume and surface area in beagle dogs: a pilot study

The objective of this study was to determine the cartilage volume and surface area of male and female Beagle dog knees using 3D (3 dimensional) reconstructed MRI images.

Authors: Aad Dhollander, Amanda Malone, James Price and Alan Getgood

Prebending of osteosynthesis plate using 3D printed models to treat symptomatic os acromiale and acromial fracture

A symptomatic os acromiale can lead to impingement syndrome and rotator cuff tendinopathy. An acromion fracture is often part of a more complex scapular trauma that needs stabilisation.

Authors: Hanne Beliën, Hanne Biesmans, Anny Steenwerckx, Eric Bijnens and Carl Dierickx

Autologous and micro-fragmented adipose tissue for the treatment of diffuse degenerative knee osteoarthritis

Chondral lesions of the knee represent a challenge for the orthopaedic surgeon. Several treatments have been proposed with variable success rate. Recently, new therapeutic approaches, such as the use of mesenc...

Authors: A. Russo, V. Condello, V. Madonna, M. Guerriero and C. Zorzi

Proximal femoral anatomy and collared stems in hip arthroplasty: is a single collar size sufficient?

Even if the benefits of collars are unclear, they remain widely used, in several femoral stem designs. This study aimed to determine whether collar size should be proportional to hip dimensions and morphology....

Authors: Nicolas Bonin, Jean-Emmanuel Gedouin, Vincent Pibarot, Jacques Bejui-Hughues, Hugo Bothorel, Mo Saffarini and Cécile Batailler

Measurement of mechanical withdrawal thresholds and gait analysis using the CatWalk method in a nucleus pulposus-applied rodent model

There are some previous reports of gait analysis using a rodent pain model. Applying the CatWalk method, objective measurements of pain-related behavior could be evaluated, but this method has not been investi...

Authors: Takuya Kameda, Yoichi Kaneuchi, Miho Sekiguchi and Shin-ichi Konno

Morphological changes in tibial tunnels after anatomic anterior cruciate ligament reconstruction with hamstring tendon graft

Three-dimensional (3D) reconstructed computed tomography (CT) is crucial for the reliable and accurate evaluation of tunnel enlargement after anterior cruciate ligament (ACL) reconstruction. The purposes of th...

Authors: Tomoki Ohori, Tatsuo Mae, Konsei Shino, Yuta Tachibana, Kazuomi Sugamoto, Hideki Yoshikawa and Ken Nakata

Is digital photography an accurate and precise method for measuring range of motion of the hip and knee?

Accurate measurements of knee and hip motion are required for management of musculoskeletal pathology. The purpose of this investigation was to compare three techniques for measuring motion at the hip and knee...

Authors: Russell R. Russo, Matthew B. Burn, Sabir K. Ismaily, Brayden J. Gerrie, Shuyang Han, Jerry Alexander, Christopher Lenherr, Philip C. Noble, Joshua D. Harris and Patrick C. McCulloch

Ground reaction forces during walking with different load and slope combinations in rats

Treadmill animal models are commonly used to study effects of exercise on bone. Since mechanical loading induces bone strain, resulting in bone formation, exercise that induces higher strains is likely to caus...

Authors: N. Bravenboer, B. T. T. M. van Rens, H. W. van Essen, J. H. van Dieën and P. Lips

Three-dimensional analysis of the tibial resection plane relative to the arthritic tibial plateau in total knee arthroplasty

Kinematically aligned total knee arthroplasty strives to correct the arthritic deformity by restoring the native tibial joint line. However, the precision of such surgical correction needs to be quantified in ...

Authors: J. Michael Johnson, Mohamed R. Mahfouz, Mehmet Rüştü Midillioğlu, Alexander J. Nedopil and Stephen M. Howell

Tendon end separation with loading in an Achilles tendon repair model: comparison of non-absorbable vs. absorbable sutures

Rupture of the Achilles tendon often leads to long-term morbidity, particularly calf weakness associated with tendon elongation. Operative repair of Achilles tendon ruptures leads to reduced tendon elongation....

Authors: Michael R. Carmont, Jan Herman Kuiper, Karin Grävare Silbernagel, Jón Karlsson and Katarina Nilsson-Helander

The biochemical and histological analysis of subcutaneous calcitonin and intramedullary methylprednisolone on bone repair after bone marrow ablation: an experimental comparative study in rats

Although, glucocorticoid (GC) and calcitonin-induced changes in bone repair have been studied previously, the exact effects of these on fracture healing remain controversial. Hence, the purpose of this experim...

Authors: Salim Ersozlu, Bartu Sarisozen, Ozgur Ozer, Saduman Balaban Adim and Orcun Sahin

Varus-valgus instability in the anterior cruciate ligament-deficient knee: effect of posterior tibial load

Anterior cruciate ligament (ACL) injury is often accompanied with medial collateral ligament (MCL) injury. Assessment of varus-valgus (V-V) instability in the ACL-deficient knee is crucial for the management o...

Authors: Tomoki Ohori, Tatsuo Mae, Konsei Shino, Yuta Tachibana, Hiromichi Fujie, Hideki Yoshikawa and Ken Nakata

Mechanical strength assessment of a drilled hole in the contralateral cortex at the end of the open wedge for high tibial osteotomy

This study aimed to investigate, by means of finite element analysis, the effect of a drill hole at the end of a horizontal osteotomy to reduce the risk of lateral cortex fracture while performing an opening w...

Authors: Arnaud Diffo Kaze, Stefan Maas, Alexander Hoffmann and Dietrich Pape

Impact of mechanical stimulation on the chondrogenic processes in human bone marrow aspirates modified to overexpress sox9 via rAAV vectors

Evaluation of gene-based approaches to target human bone marrow aspirates in conditions of mechanical stimulation that aim at reproducing the natural joint environment may allow to develop improved treatments ...

Authors: Jagadeesh K. Venkatesan, Janina Frisch, Ana Rey-Rico, Gertrud Schmitt, Henning Madry and Magali Cucchiarini

Geometric morphometric analysis reveals age-related differences in the distal femur of Europeans

Few studies have looked into age-related variations in femur shape. We hypothesized that three-dimensional (3D) geometric morphometric analysis of the distal femur would reveal age-related differences. The pur...

Authors: Etienne Cavaignac, Frederic Savall, Elodie Chantalat, Marie Faruch, Nicolas Reina, Philippe Chiron and Norbert Telmon

Dynamic radiostereometric analysis for evaluation of hip joint pathomechanics

Dynamic RSA (dRSA) enables non-invasive 3D motion-tracking of bones and may be used to evaluate in-vivo hip joint kinematics including hip pathomechanics such as femoroacetabular impingement (FAI) and the biom...

Authors: Lars Hansen, Sepp de Raedt, Peter Bo Jørgensen, Bjarne Mygind-Klavsen, Bart Kaptein and Maiken Stilling

Autofluorescence imaging for improved visualization of joint structures during arthroscopic surgery

The purpose of our study is to develop the arthroscopic autofluorescence imaging (AFI) system to improve the visualization during arthroscopic surgery by real-time enhancing the contrast between joint structur...

Authors: Duy Tan Nguyen, Pepijn van Horssen, Hans Derriks, Martijn van de Giessen and Ton van Leeuwen

Current trends in tendinopathy: consensus of the ESSKA basic science committee. Part I: biology, biomechanics, anatomy and an exercise-based approach

Chronic tendinopathies represent a major problem in the clinical practice of sports orthopaedic surgeons, sports doctors and other health professionals involved in the treatment of athletes and patients that p...

Authors: F. Abat, H. Alfredson, M. Cucchiarini, H. Madry, A. Marmotti, C. Mouton, J.M. Oliveira, H. Pereira, G. M. Peretti, D. Romero-Rodriguez, C. Spang, J. Stephen, C. J. A. van Bergen and L. de Girolamo

Does anatomic single-bundle ACL reconstruction using hamstring autograft produce anterolateral meniscal root tearing?

To determine if tibial tunnel reaming during anatomic single-bundle anterior cruciate ligament (ACL) reconstruction using hamstring autograft can result in anterolateral meniscal root injury, as diagnosed by m...

Authors: Sebastián Irarrázaval, Angel Masferrer-Pino, Maximiliano Ibañez, Tamer M. A. Shehata, María Naharro and Joan C. Monllau

The effect of repetitive flexion and extension fatigue loading on the young porcine lumbar spine, a feasibility study of MRI and histological analyses

The biomechanical mechanisms of failure of FSUs have been studied but the correlation of repetitive flexion and extension loadings to the initial phase of fatigue in young FSUs are still not known. The purpose...

Authors: Olof Thoreson, Lars Ekström, Hans-Arne Hansson, Carl Todd, Wisam Witwit, Anna Swärd Aminoff, Pall Jonasson and Adad Baranto

The rate of publication of free papers at the 2008 and 2010 European Society of Sports Traumatology Knee Surgery and Arthroscopy congresses

The purpose of this study was to evaluate the frequency with which free papers presented at the 2008 and 2010 European Society of Sports Traumatology Knee Surgery and Arthroscopy (ESSKA) congress were ultimate...

Authors: Jeffrey Kay, Muzammil Memon, Joelle Rogozinsky, Darren de SA, Nicole Simunovic, Romain Seil, Jon Karlsson and Olufemi Rolland Ayeni

Hyaluronan thiomer gel/matrix mediated healing of articular cartilage defects in New Zealand White rabbits—a pilot study

Articular cartilage defects are limited to their regenerative potential in human adults. Our current study evaluates tissue regeneration in a surgically induced empty defect site with hyaluronan thiomer as a p...

Authors: Christoph Bauer, Vivek Jeyakumar, Eugenia Niculescu-Morzsa, Daniela Kern and Stefan Nehrer

Three-dimensional geometric morphometric analysis reveals ethnic dimorphism in the shape of the femur

Ethnic dimorphism in the distal femur has never been studied in a three-dimensional analysis focused on shape instead of size. Yet, this dimorphism has direct implications in orthopedic surgery and in anthropo...

Authors: Etienne Cavaignac, Ke Li, Marie Faruch, Frederic Savall, Philippe Chiron, W. Huang and Norbert Telmon

The cytokine expression in synovial membrane and the relationship with pain and pathological findings at hip arthroscopy

Synovial membrane inflammation is the most common finding presenting during hip arthroscopy, and may play a role in hip pain. We sought to determine the relationships between synovial cytokine levels, hip pain...

Authors: Kensuke Fukushima, Gen Inoue, Hisako Fujimaki, Kentaro Uchida, Masayuki Miyagi, Naoshige Nagura, Katsufumi Uchiyama, Naonobu Takahira and Masashi Takaso

A retinaculum-sparing surgical approach preserves porcine stifle joint cartilage in an experimental animal model of cartilage repair

This study compares a traditional parapatellar retinaculum-sacrificing arthrotomy to a retinaculum-sparing arthrotomy in a porcine stifle joint as a cartilage repair model.

Authors: Marcelo B. Bonadio, James M. Friedman, Mackenzie L. Sennett, Robert L. Mauck, George R. Dodge and Henning Madry

The effect of a dynamic PCL brace on patellofemoral compartment pressures in PCL-and PCL/PLC-deficient knees

The natural history of posterior cruciate ligament (PCL) deficiency includes the development of arthrosis in the patellofemoral joint (PFJ). The purpose of this biomechanical study was to evaluate the hypothes...

Authors: Tyler Welch, Thomas Keller, Ruben Maldonado, Melodie Metzger, Karen Mohr and Ronald Kvitne

Biomechanical cadaveric comparison of patellar ligament suture protected by a steel cable versus a synthetic cable

Purpose and hypothesis: Patellar ligament rupture is a rare disabling pathology requiring a surgical ligament suture protected by a frame. The gold standard is the steel cable, but its rigidity and the necessi...

Authors: P. Bouget, C. Breque, J. S. Beranger, J. P. Faure, F. Khiami and T. Vendeuvre

Different culture conditions affect the growth of human tendon stem/progenitor cells (TSPCs) within a mixed tendon cells (TCs) population

Tendon resident cells (TCs) are a mixed population made of terminally differentiated tenocytes and tendon stem/progenitor cells (TSPCs). Since the enrichment of progenitors proportion could enhance the effecti...

Authors: M. Viganò, C. Perucca Orfei, A. Colombini, D. Stanco, P. Randelli, V. Sansone and L. de Girolamo

Differences in biomarkers of cartilage matrix turnover and their changes over 2 years in adolescent and adult volleyball athletes

This study aimed the feasibility to assess longitudinal changes in biomarkers of cartilage turnover and to determine their relationship with patient-rated outcomes over 2 years in volleyball athletes.

Authors: Heide Boeth, Aoife MacMahon, A. Robin Poole, Frank Buttgereit, Patrik Önnerfjord, Pilar Lorenzo, Cecilia Klint, Anna Pramhed and Georg N. Duda

MRI findings of knee abnormalities in adolescent and adult volleyball players

To longitudinally and cross-sectionally evaluate knee abnormalities by sex and age in adolescent and adult volleyball athletes over 2 years using magnetic resonance imaging (MRI).

Authors: Heide Boeth, Aoife MacMahon, Felix Eckstein, Gerd Diederichs, Arne Schlausch, Wolfgang Wirth and Georg N. Duda

The haematoma and its role in bone healing

Fracture treatment is an old endeavour intended to promote bone healing and to also enable early loading and regain of function in the injured limb. However, in today’s clinical routine the healing potential o...

Authors: H. Schell, G. N. Duda, A. Peters, S. Tsitsilonis, K. A. Johnson and K. Schmidt-Bleek

Effects of combined rAAV-mediated TGF-β and sox9 gene transfer and overexpression on the metabolic and chondrogenic activities in human bone marrow aspirates

Transplantation of genetically modified bone marrow concentrates is an attractive approach to conveniently activate the chondrogenic differentiation processes as a means to improve the intrinsic repair capacit...

Authors: Ke Tao, Ana Rey-Rico, Janina Frisch, Jagadeesh Kumar Venkatesan, Gertrud Schmitt, Henning Madry, Jianhao Lin and Magali Cucchiarini

A preclinical numerical assessment of a polyetheretherketone femoral component in total knee arthroplasty during gait

Conventional total knee replacement designs show high success rates but in the long term, the stiff metal components may affect bone quality of the distal femur. In this study we introduce an all-polymer total...

Authors: Lennert de Ruiter, Dennis Janssen, Adam Briscoe and Nico Verdonschot

Biomechanical testing of transcapsular meniscal repair

All of previous biomechanical studies on meniscal repair have examined the meniscus itself without synovial membrane and capsule, although in the clinical setting, the meniscal repair is generally performed in...

Authors: Ryo Iuchi, Tatsuo Mae, Konsei Shino, Tomohiko Matsuo, Hideki Yoshikawa and Ken Nakata

Patient perceptions regarding physician reimbursements, wait times, and out-of-pocket payments for anterior cruciate ligament reconstruction in Ontario

Currently, there is a lack of knowledge regarding patient perceptions surrounding physician reimbursements, appropriate wait times, and out-of-pocket payment options for anterior cruciate ligament reconstructi...

Authors: Muzammil Memon, Lydia Ginsberg, Darren de SA, Andrew Nashed, Nicole Simunovic, Mark Phillips, Matthew Denkers, Rick Ogilvie, Devin Peterson and Olufemi R. Ayeni

Erratum to: Bone marrow aspirate concentrate for the treatment of osteochondral lesions of the talus: a systematic review of outcomes

Authors: Jorge Chahla, Mark E. Cinque, Jason M. Schon, Daniel J. Liechti, Lauren M. Matheny, Robert F. LaPrade and Thomas O. Clanton

Drill wobble – effect on femoral tunnel aperture during anterior cruciate ligament reconstruction

In anterior cruciate ligament reconstruction performed using cortical button fixation on the femur, we have observed a “wobble” effect that can occur when a cannulated femoral drill is used over a guide pin th...

Authors: Naser Alnusif, Adam Hart, Maher Baroudi, Robert Marien, Mark Burman and Paul A. Martineau

Quantitative Computed Tomography (QCT) derived Bone Mineral Density (BMD) in finite element studies: a review of the literature

Finite element modeling of human bone provides a powerful tool to evaluate a wide variety of outcomes in a highly repeatable and parametric manner. These models are most often derived from computed tomography ...

Authors: Nikolas K. Knowles, Jacob M. Reeves and Louis M. Ferreira

Anatomical study: comparing the human, sheep and pig knee meniscus

Animal models are commonly used in investigating new treatment options for knee joint injuries including injuries to the meniscus. The reliability and applicability of these models to replicate findings in hum...

Authors: Talal Takroni, Leila Laouar, Adetola Adesida, Janet A. W. Elliott and Nadr M. Jomha

Randomized controlled trial comparing the effectiveness of the ultrasound-guided galvanic electrolysis technique (USGET) versus conventional electro-physiotherapeutic treatment on patellar tendinopathy

Patellar tendinopathy has a high prevalence rate among athletes. Different therapeutic options can be found in the current literature, but none of them has been clearly established as the gold standard. The pu...

Authors: F. Abat, J. L. Sánchez-Sánchez, A. M. Martín-Nogueras, J. I. Calvo-Arenillas, J. Yajeya, R. Méndez-Sánchez, J. C. Monllau and P. E. Gelber

Bone marrow aspirate concentrate for the treatment of osteochondral lesions of the talus: a systematic review of outcomes

The goal of this perform a systematic review on the outcomes of bone marrow aspirate concentrate (BMAC) for the treatment of chondral defects and osteoarthritis (OA) of the talus.

Authors: Jorge Chahla, Mark E. Cinque, Jason M. Schon, Daniel J. Liechti, Lauren M. Matheny, Robert F. LaPrade and Thomas O. Clanton