- Original Paper
- Open Access
Insall proximal realignment with/without tibial tubercle osteotomy for recurrent patellar instability yields acceptable medium- to long-term results but risk of osteoarthritis progression is considerable
Journal of Experimental Orthopaedics volume 9, Article number: 64 (2022)
The purpose of this study was to evaluate clinical and radiological results in patients operated for recurrent patellar instability with a surgical approach consisting of Insall proximal realignment with/without tibial tubercle osteotomy (TTO).
Patients that underwent surgery for recurrent patellar instability at one centre with a uniform technique between 2004 and 2020 were included. Eligible patients were assessed by clinical examination and the disease-specific Banff Patellofemoral Instability Instrument 2.0 (BPII 2.0). Pre- and postoperative radiographs were analysed for patellofemoral osteoarthritis (OA) according to Iwano. Preoperative Magnetic Resonance Imaging (MRI) and radiographs were analysed for anatomical risk factors for patellar instability. Student t-test, chi-square test and ANOVA-analyses were used to investigate whether anatomical risk factors and/or patient characteristics could predict an inferior outcome.
Forty-six patients (47 knees) were included at a mean follow-up time of 6.6 years (SD 4.6; range 1–17). Mean BPII 2.0 score was 60.4 (SD 18.4; range 26–98), and 10.6% (n = 5) had suffered a postoperative redislocation. Progression to evident patellofemoral OA was seen in 15% of the patients (p < 0.05). The presence of pathoanatomic risk factors did not correlate with recurrent postoperative instability or inferior BPII 2.0 score at the final evaluation.
Patients treated with the current approach reported acceptable medium- to long-term results, but the risk of patellofemoral OA progression is significant. These findings add to the knowledge of expected outcomes after procedures involving Insall proximal realignment, and can guide clinical decision making for surgeons using similar methods.
Level of evidence
Level IV, case series.
Adolescents and young adults suffering from recurrent patellar instability experience pain and undesired reduction in their level of activity. Current guidelines support that surgery is an important part of the treatment strategy . The Insall proximal realignment procedure has historically been an important soft - tissue technique, and was also proposed for treating quadriceps dysplasia by Dejour et al. . The goal was to strengthen the dynamic stabilisation of the patella by lateralization of the vastus medialis muscle insertion combined with a lateral retinacular release . A systematic review found an acceptable failure rate of 6.3% after such procedures, but indications for surgery, outcome assessment measures, and surgical techniques were highly divergent between studies included in that summary .
In light of the focus on the medial patellofemoral ligament (MPFL) as the main ligamentous restraint of lateral excursion of the patella , reconstruction of the MPFL (MPFL-R) has largely replaced other soft tissue procedures in current treatment algorithms . Several recent reports also criticise proximal realignment procedures as a non–anatomic approach that might increase the risk for patellofemoral osteoarthritis (OA) [13, 39]. However, few studies have applied validated disease-specific patient reported outcome measures (PROMs) - and radiographic evaluation - to evaluate patients treated with such procedures. The Kujala score, frequently used in evaluating this patient category , was originally developed for anterior knee pain. It therefore includes only one question directly inquiring patellar instability. In search of more valid and reliable outcome measures, Banff Patella Instability Instrument 2.0 (BPII 2.0) was recently developed .
The aim of the present study is therefore to use BPII 2.0 to evaluate a consecutive series of patients treated with a surgical approach consisting of Insall proximal realignment with/without tibial tubercle osteotomy (TTO). It was hypothesised that excessive pathoanatomic risk factors in patients could predict inferior results and increase the risk of patellofemoral OA progression.
Materials and methods
All patients surgically treated for recurrent patellar instability at a single centre between 2004 and 2020 were retrospectively identified and included in the study. Exclusion criteria included former stabilising surgery, surgery after first-time patellar dislocations due to osteochondral injuries, patellofemoral pain as indication for surgery, concomitant anterior cruciate ligament reconstruction and procedures involving knee replacement. All surgeries were performed by one out of two experienced knee surgeons. Eligible patients were contacted and offered a follow-up examination with questionnaires, clinical examination, radiographs and functional testing. Ethical approval was obtained from the Regional Committee for Medical and Health Research Ethics West 2020/183361. Written informed consent was obtained from all subjects before enrolment into the study.
The incidence of postoperative recurrent patellar instability and reoperations were registered. Questionnaires were administered at the follow-up examination. The BPII 2.0 is a Quality of Life (QOL) score ranging from 0 to 100 where a higher score indicates a higher QOL . The Norwegian version is currently in a validation process, so far demonstrating good psychometric properties in several domains . The Kujala score has also been translated and validated in Norwegian . In addition to the above PROMs, patients graded their overall satisfaction with the procedure on a visual analogue scale (VAS) ranging from 0 to 100  where a higher score indicates greater satisfaction.
Clinical examination and functional testing
Evaluation was performed by two independent examiners not formerly involved in patient care. Body mass index (BMI), varus/valgus alignment of the knee, swelling, crepitus, presence of J-sign and range of motion (ROM) of the hip and knee were assessed. Reverse dynamic patellar apprehension test (ReDPAT)  was performed and graded. Return to sport (RTS) readiness assessment included the Lower Quarter-Balance Test (YBT-LQ)  and single-legged hop tests . RTS readiness criteria were defined as an anterior reach asymmetry of < 4 cm  for the YBT-LQ and leg symmetry index (LSI) > 85%  for hop-testing. Patients who had undergone subsequent surgery in the opposite knee were excluded from the RTS analysis.
Pre- and postoperative radiographs (Merchant view) were evaluated for patellofemoral OA according to the Iwano grading system , and evident patellofemoral OA was defined as moderate to very severe joint space narrowing (Iwano grade 2–4) . Patellar morphology was classified according to a simplified Wiberg-Baumgartl classification as grade 1, 2, 3 and “Jägerhut” .
Preoperative Magnetic Resonance Imaging (MRI) scans were assessed to identify anatomical risk factors for patellar instability. Lateral Trochlear Inclination (LTI) was evaluated using a modified version of the two-slice technique described by Joseph et al. , and values ≤11 degrees were considered as trochlear dysplasia. Using the same cranial image, trochlear dysplasia was evaluated qualitatively according to the Oswestry-Bristol Classification (OBC) . Patellar height was evaluated on MRI by measuring Caton-Deschamps index (CDI) and Patellotrochlear index (PTI) on sagittal images , and patella alta was defined as CDI > 1.2  or PTI < 0.18% . The tuberositas tibia-trochlear groove (TT-TG) distance was measured by using a sticky note as described by Camp et al. . The cut - off for an increased TT - TG distance was set to ≥15 mm.
To evaluate interrater reliability, two independent orthopaedic surgeons (P.A.S.W. and E.I.) analysed selected radiological measurements in a blinded fashion. Assessment was then repeated by one of the surgeons after six weeks for calculating the intrarater reliability.
Surgical technique and postoperative restrictions
The proximal realignment procedure is performed through a 7–8 cm midline incision as previously described by Insall , with a 2–3 cm plication of the vastus medialis tendon and medial capsule in a lateral direction. The lateral retinacular release respects the capsule. Before final tightening of the non-absorbable sutures fixating the medial plication, the knee is brought through a full ROM to check patellar tracking and the integrity of the stitches. A concomitant medialization TTO was considered by the surgeon if the patient had a clinically increased q - angle with a subluxated patella throughout the axial MRI series. A procedure involving TTO is done through the same incision extended distally. First the lateral release is performed, followed by an osteotomy of the tibial tubercle, sparing a distal part attached to tendon and fascia. The tubercle is medialized to the point where optimal patellar tracking is achieved (maximum 1.5 cm) and fixed with screws. Finally the medial plication is conducted as described.
Postoperative restrictions allow ROM up to 90 degrees of flexion and brace-free full weight-bearing on a straight knee for the first 4 weeks. Free ROM was then allowed. When an isolated Insall proximal realignment was performed, patients could start full weight-bearing after 4 weeks. When combined with TTO, full weight-bearing was allowed after 6 weeks.
All statistical analyses were performed using the IBM SPSS Statistics for Windows, version 26.0 (IBM Corp). The a priori significance level was set to 0.05. Normality was assessed by the Kolmogorov-Smirnov test. Independent sample t-test was conducted to investigate any relationship between PROMs and (1) the presence/absence of pathoanatomic risk factors (such as trochlear dysplasia, high TT - TG distance and patella alta) and (2) different demographic features. One-way ANOVA analysis was used to explore the impact of categorical pathoanatomic risk factors with three or more groups on PROMs. Pearson r for parametric variables or Spearman rho for non-parametric variables were calculated to determine any correlation between PROMs and different pathoanatomic and demographic continuous variables. Chi-square test for independence was used to compare pathoanatomic risk factors in patients with postoperative repeat patellar instability and those who were stable. Inter- and intrarater reliability was calculated and graded by using intraclass correlation coefficient (ICC) for continuous data , and Krippendorff’s alpha  and percentage of agreement for ordinal data.
Forty-six patients (47 knees) with a mean age of 21.7 years (SD 6.5; range 13–41) were included in the study (Fig. 1), whereof 41 (87.2%) were treated with an isolated Insall procedure. Ninety - 3 % of eligible patients were available for the follow-up examination at a mean of 6.6 years (SD 4.6; range 1–17) after surgery. Additional demographic data are listed in Table 1.
Outcomes at follow-up
At the time of follow-up, 5 patients (10.6%) had suffered a redislocation and further 8 patients (17.0%) described at least one episode with subluxation of the patella. The overall reoperation rate among the included patients was 15.2% (n = 7): revision stabilization procedure (n = 2), revision of a superficial wound infection (n = 1), drainage of a postoperative hematoma (n = 2), hardware removal (n = 1) and knee arthroscopy with removal of scar tissue (n = 2). Mean BPII 2.0 score was 60.4 (SD 18.4; range 26–98), mean Kujala score was 75.4 (SD 14.7; range 40–100) and mean VAS of satisfaction was 78.4 (SD 26.0; range 1–10) at the follow-up evaluation. No significant differences in outcome measurements between surgical procedures (Insall with/without TTO) were found (n.s), see Table 2.
Clinical and radiological findings
Knee ROM deficit ≥10 degrees was more frequently in knees operated with a combined Insall and TTO (p < 0.05). Additional clinical findings and RTS readiness rates are summarised in Table 3.
Differences in pathoanatomic MRI features between the surgical procedures (Insall with/without TTO) are listed in Table 2. A general high frequency of patellofemoral pathoanatomic risk factors were found on the radiological evaluation (Table 4). A significant progression to evident patellofemoral OA was seen from baseline to the follow-up evaluation - from 9% to 24% respectively (p < 0.05).
Substantial intrarater, but low interrater reliability was found for the ordinal variables (OBC and Iwano). Both inter- and intrarater reliability were considered either good or excellent for all the continuous variables (LTI, TT - TG, CDI). Additional information about reliability analyses is provided in Table 5.
Predictors for inferior outcomes
Neither demographic factors, findings at clinical examination nor inability to meet the RTS criteria correlated with an inferior BPII 2.0 (n.s) at follow-up. BPII 2.0 score was slightly higher in patients with follow up ≥3 years compared to those with follow up < 3 years (61.4; SD 16.0; range 26–98 versus 57.9; SD 16.0; range 34.5–92.0), but the difference was not significant (n.s). Further, no differences in scores were found between those with a stable patella and those who had postoperative repeat instability (n.s).
No correlation was found between inferior BPII 2.0 score and (a) severity of trochlear dysplasia, (b) patella alta or (c) increased TT-TG distance. Even if (a)-(c) were combined for analyses, there was no relationship between pathoanatomical features and risk of inferior scores (n.s.). Further, the presence and severity of pathoanatomic factors did not increase the risk of undergoing any later surgery. A higher frequency of postoperative recurrent instability was seen in those with a patella alta (p < 0.05) when defined as CDI > 1.2. No such relationship was evident for the other pathoanatomical features. Increasing Wiberg grade of the patella did neither lead to an inferior BPII 2.0 score, nor did it increase the risk of recurrent postoperative instability (n.s).
Four patients had evident preoperative patellofemoral OA. These had a significantly lower BPII 2.0 score at follow-up when compared to the rest of the cohort (42.0 versus 62.1, p < 0.05). There was also a tendency towards lower BPII 2.0 scores in those who had a preoperative Iwano grade 0–1 with a progression to Iwano grade ≥ 2 postoperatively (47.3 versus 62.9, n.s). No significant differences of patellofemoral OA progression were seen in those with long-term (> 5 years) follow-up after surgery compared to those at medium-term (1–5 years) after surgery. Trochlear dysplasia defined as LTI ≤11 degrees did not correlate with progression of patellofemoral OA (n.s).
The main finding of the current study is an overall VAS of satisfaction with surgery of 78.4, a mean BPII 2.0 score of 60.4 and a 10.6% redislocation rate at 6.6 years follow-up after an Insall proximal realignment procedure with/without TTO for patients with recurrent patellar instability. Further, although a non-anatomic surgical approach was applied to the current cohort - pathoanatomical risk factors for instability did not predict inferior clinical outcomes. Overall, the incidence of patellofemoral OA increased substantially from baseline to the mid- to long-term radiologic evaluation.
To date, no other studies have evaluated a treatment algorithm based on Insall proximal realignment with a multitudinous approach, including a validated disease-specific PROM. This allows for comparison across studies applying different surgical approaches for recurrent patellar instability. A few recent studies report BPII 2.0 scores after MPFL-R with/without additional individualised procedures. Both Zimmermann and Börtlein  and Hiemstra et al.  found an increase in BPII 2.0 score from pre – to postoperatively from 29 and 28, to 76 and 74, respectively. Although the mean postoperative score in these studies is higher compared to the current patient series, the follow-up time is considerably shorter and it is unclear whether patients with preoperative signs of patellofemoral OA were included in those studies. In the current study, patients with evident preoperative OA displayed significantly lower BPII 2.0 scores at the final evaluation, regardless of follow-up time.
Compared to the mean Kujala score of 75.4 in the current study, Efe et al.  found a higher mean score of 85 at 4 years in 46 patients treated with Insall proximal realignment. In that study, however, Kujala scores as high as 100 were recorded. This ceiling effect, along with the fact that only one question concerns patellofemoral instability, illustrates the limitations of using the Kujala score as a primary outcome measure when evaluating patients with patellar instability .
In the current cohort, 10.6% of patients suffered from a redislocation- with an additional 17.0% describing at least one episode of patellar subluxation throughout the follow-up period. In the comparable study by Efe et al. , where patients treated solely with the Insall proximal realignment procedure were included, a higher redislocation rate of 22% was seen. This difference in findings might be due to the inclusion of TTO in the current treatment strategy. In comparison, studies applying modern MPFL-R - regardless of pathoanatomic features of treated knees - redislocation and/or subluxation rates between 3.4% and 8.4% [18, 43] have been seen. One of the few other studies reporting both on luxation and subluxation rates after MPFL-R with/without TTO is that by Enderlein et al. . They observed a redislocation rate of 4.5% and a subluxation rate as high as 39%. Both differences in surgical approach for patellar and heterogeneous definitions of recurrent instability/failure can explain the range in failure rates seen across different patient cohorts .
Patients with recurrent patellar instability have an increased risk of developing patellofemoral OA. Even if surgery can reduce the risk of OA development , several long-term studies report a significant progression of patellofemoral OA at follow-up evaluation [7, 35, 41]. Recent publications on MPFL-R report minimal patellofemoral OA progression [31, 42]. These, however, often exclude patients with excessive pathoanatomic features or include only short- to medium term results. In the current cohort, progression from Iwano 0–1 to Iwano ≥2 (evident patellofemoral OA) was seen in 15% of the patients. Schuttler et al.  reported a somewhat higher rate of patellofemoral OA progression - of 43% - in a patient series treated with an isolated Insall technique. That study also included patients without preoperative radiographs - introducing a potential bias in the reporting. Those with trochlear dysplasia seem to have a particular risk patellofemoral OA development , but no such correlation was found in the current patient series.
Detection of one or more common pathoanatomical risk factors on preoperative imaging (trochlear dysplasia, patella alta or increased TT – TG distance) or postoperative clinical examination (valgus malalignment, increased femoral anteversion, positive reDPAT) did not predict an inferior patient reported function in the current study. In fact, the tendency was an inverse relationship displaying better BPII 2.0 scores for those with a more severe trochlear dysplasia. The same tendency was seen when several risk factors were combined. These results correspond to findings by Hiemstra et al. , demonstrating how bilateral symptoms and younger age at first dislocation, but not pathoanatomic features, predicted a lower BPII score in patients operated with isolated MPFL-R. Other studies have demonstrated that female gender, higher age and increased BMI at the time of surgery can predict inferior outcomes [9, 15]. Conversely, the current study could not find a significant correlation between any demographic features and inferior BPII 2.0 score.
In the current patient series, patella alta defined as CDI > 1.2 was significantly more present in patients with postoperative recurrence of patellar instability, corroborating results from other surgical approaches . However, only one of these patients had patella alta defined as PTI < 18%, illustrating a potential bias when using measurements developed for lateral radiographs on sagittal MRIs . Other studies have found that trochlear dysplasia, either alone or in combination with other anatomical risk factors such as patella alta, a lateralized tibial tubercle, valgus malalignment and/or increased femoral anteversion, is the most important risk for failure in MPFL-R based treatment algorithms . Yet again, other authors have seen no correlation between recurrent postoperative dislocations and trochlear dysplasia, patella alta and/or increased TT-TG distance . These diverging findings might be explained by inherent limitations in methods used to measure the different risk factors . The TT – TG distance, for example, can be influenced by several potential confounding factors, and recently published work suggests that other parameters, such as the tibial tubercle – midepicondyle distance, can be more reliable in predicting recurrent instability after MPFL – reconstruction . Thus, the findings both in the current work and similar studies should be interpreted cautiously.
The current study has several limitations. Most importantly, no PROMs were collected prior to surgery - and there was no control group. Hence, it is not possible to isolate the potential effectiveness of the current surgical approach. Nevertheless, indications for surgery, patient demographic and pathoanatomic features reflect other similar published case series - allowing a cautious extrapolation of treatment effect from the current cohort. Further, patient satisfaction with the procedure indicates an overall effect on their quality of life. Several patients did not have preoperative lateral radiographs available, and CDI had to be measured on MRI. This could lead to a possible bias in the reporting of patella alta, but PTI was also included in the evaluation. MRI scans were obtained from several institutions and differences in protocols can influence measurements. A certain variation, however, reflects everyday life in clinical practice and measurements for evaluating patellar instability should be sturdy enough to overcome such issues. With only a moderate size of this cohort, generalisation of the findings should be done with care. On the other hand, 93% of patients eligible for the study were available at follow-up and these results should therefore reflect well on the population treated for patellar instability at the current clinic.
This is the first study to report on mid- to long-term results after Insall proximal realignment with/without TTO for recurrent patellar instability applying a multitudinous approach including disease-specific and validated outcome measures. Although one out of three patients experienced some sort of persistent instability and a significant progression of patellofemoral OA was seen, patients treated with the current approach reported an overall good satisfaction with results after surgery and acceptable medium- to long-term results.
Availability of data and materials
The datasets used and/or analysed during the current study are available from the corresponding author on reasonable request.
Tibial tubercle osteotomy
- BPII 2.0:
Banff Patellofemoral Instability Instrument 2.0
Magnetic Resonance Imaging
Medial patellofemoral ligament
Medial patellofemoral ligament reconstruction
Patient reported outcome measures
Visual analogue scale
Body mass index
Range of motion
Reverse dynamic patellar apprehension test
Return to sport
Lower Quarter-Balance Test
Quality of Life
Lateral Trochlear Inclination
Tuberositas tibia-trochlear groove
Intraclass correlation coefficient
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Thanks to Anja Senneset at Lærdal Hospital for her great contribution in patient logistics.
Partial financial support of NOK 210 000,- was received from Førde Health Thrust, covering study expenses.
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Approval was obtained from the Regional Committee for Medical and Health Research Ethics West (Date/approval number 2020/183361). Written informed consent was obtained from all individual participants included in the study.
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Waaler, P.A.S., Jellestad, T., Hysing-Dahl, T. et al. Insall proximal realignment with/without tibial tubercle osteotomy for recurrent patellar instability yields acceptable medium- to long-term results but risk of osteoarthritis progression is considerable. J EXP ORTOP 9, 64 (2022). https://doi.org/10.1186/s40634-022-00502-x
- Patellar instability
- Patellar dislocation
- Proximal realignment
- Tibial tubercle osteotomy
- Oswestry-Bristol classification
- Trochlear dysplasia