Fig. 3

FSCs from patients grouped by high (black circles) and low (gray circles) SFb remained untreated (NT) or were treated with MXD in the presence or absence of TGFβ1 stimulation. A-A” COL1 output was measured and compared between groups and the effect of MXD treatment on unstimulated or TGFβ1-stimulated FSCs from each patient is shown. B-B” The effect on Pyd content was also measured under the same conditions. *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001, no asterisk: p > 0.05