Table 6 Best-evidence-synthesis of miRNAs associated with tendinopathies or tendon ruptures
Study | miRNA | Expression pattern | Sample | Study quality | Overall Rating | |
|---|---|---|---|---|---|---|
Plachel et al. [41] Thankam et al. [40] Thankam et al. [54] | 25-3p | ↓ ↓ ↓ | Venous blood Bicep tendon Bicep tendon | High Quality Borderline Borderline | Moderate evidence | |
Plachel et al. [41] Hall et al. [43] Thankam et al. [40] Leal et al. [44] Thankam et al. [54] | 29a-3p | ↓ ↓ ↓  →  ↓ | Venous blood, SSP/SSC tendon SSP/SSC tendon Bicep tendon SSP tendon Bicep tendon | High Quality Acceptable Borderline Acceptable Borderline | Moderate evidence | |
Plachel et al. [41] Thankam et al. [40] Thankam et al. [54] | 140-3p | ↓ ↓ ↓ | Venous blood, SSP/SSC tendon Bicep tendon Bicep tendon | High Quality Borderline Borderline | Moderate evidence | |
Plachel et al. [41] Thankam et al. [40] | 425-5p | ↓ ↓ | Venous blood Bicep tendon | High Quality Borderline | Moderate evidence | |
Thankam et al. [55] Thankam et al. [40] | 99a-5p | ↓ ↓ | Bicep tendon Bicep tendon | Borderline Borderline | Limited evidence | |
Thankam et al. [55] Thankam et al. [40] Thankam et al. [54] | 145-5p | ↓ ↓ ↓ | Bicep tendon Bicep tendon Bicep tendon | Borderline Borderline Borderline | Limited evidence | |
Hall et al. [43] Thankam et al. [40] Thankam et al. [54] | 151a-3p | ↓ ↓ ↓ | SSP/SSC tendon Bicep tendon Bicep tendon | Acceptable Borderline Borderline | Limited evidence | |
Hall et al. [43] Thankam et al. [40] | 191-5p | ↓ ↓ | SSP/SSC tendon Bicep tendon | Acceptable Borderline | Limited evidence | |
Hall et al. [43] Thankam et al. [40] Thankam et al. [54] | 199a-5p | ↓ ↓ ↓ | SSP/SSC tendon Bicep tendon Bicep tendon | Acceptable Borderline Borderline | Limited evidence | |
Thankam et al. [55] Thankam et al. [40] | 297 | ↑ ↑ | Bicep tendon Bicep tendon | Borderline Borderline | Limited evidence | |
Hall et al. [43] Thankam et al. [40] Thankam et al. [54] | 532-5p | ↓ ↓ ↓ | SSP/SSC tendon Bicep tendon Bicep tendon | Acceptable Borderline Borderline | Limited evidence | |
Thankam et al. [55] Thankam et al. [40] Thankam et al. [54] | let-7b-5p | ↓ ↓ ↓ | Bicep tendon Bicep tendon Bicep tendon | Borderline Borderline Borderline | Limited evidence | |
Thankam et al. [55] Hall et al. [43] Thankam et al. [40] | 100-5p | ↓  →  ↓ | Bicep tendon SSP/SSC tendon Bicep tendon | Borderline Acceptable Borderline | Conflicting evidence | |
Plachel et al. [41] Hall et al. [43] | 222-3p | ↓  →  | Venous blood SSP/SSC tendon | High quality Acceptable | Conflicting evidence | |
Xiao et al. [57] Millar et al. [51] | 29a |  →   →  | Patellar tendon SSP/SSC tendon | Borderline Borderline | No evidence | |
Leal et al. [44] Lu et al. [50] | 29b-3p |  →   →  | SSP tendon Hamstring tendon | Acceptable Borderline | No evidence | |
Brown et al. [46] Abrahams et al. [45] | 608 |  →   →  | Saliva Unclear | Borderline Borderline | No evidence | |
Ge et al. [42] Thankam et al. [40] | 1273 g-3p |  →  ↓ | SSP tendon Bicep tendon | Acceptable Borderline | No evidence | |