Table 1 Cryotherapy and pain management protocols comparison between both groups

Cryotherapy device

Static compression cryotherapy with Igloo® device

Dynamic intermittent compression cryotherapy utilizing CryoNov® device from Orthonov

Cryotherapy protocol

Positioned by the surgeon at the end of the procedure and was turned on for 30 min and off for 2 h for 5 days. The device is removed at night

positioned by the surgeon at the end of the procedure, then programmed to turn on for 30 and 30 min off at low pressure for 5 days. The device is removed at night

Common oral medication

Classic 8-day systematic pain relief protocol. This protocol included 200 mg of oral Celecoxib twice daily, Lamaline (Paracetamol/opium) 500 mg/25 mg every 8 h, Omeprazol 20 mg/day, Paracetamol 500 mg every 8 h, and

Nefopam

Oral Nefopam 20 mg/2 mL every 8 h

Intravenous administration of 3 vials of Nefopam 20 mg/2 ml diluted in 50 ml of normal saline solution (9%) a continuous IV for 12 h every 12 h,

Other intravenous (IV) medication^a

1 vial of (IV) metoclopramide 10 mg/2 mL diluted in 50 mL of normal saline for 30 min every 12 h