Fig. 5

Quantitative differences in the spatial patterns of bone regeneration after five weeks post trauma (wpt). The figure shows the bone area across the 3.07 ± 0.09 mm distance, represented as percent of defect, extending from the proximal (0%) to the distal (100%) defect borders. The cross-sectional bone area (mean ± SEM) was calculated for each trans axial slice (13 µm) to access spatial bone regeneration and remodeling trends for vehicle and RU.521 treatment groups after 5 weeks post treatment. n = 5/vehicle control and n = 8/RU.521 treatment. Data are graphically represented as mean ± SEM