Table 1 Treatment allocation, and histology subcategory scores for individual rats. 0 = None, 1 = Mild, 2 = Moderate, 3 = Severe, x = unable to score. Histology failed in one rat (rat 8 – D5S). DD = dose-dump administration, SUS = sustained administration
Animal ID | Concentration (%) | Profile | Assessment | Necrosis | Fibrosis | Muscle | Inflammation | Bone damage | Periosteal reaction | Osteoblasts | Histiocytes | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Fibrosis | Atrophy | Calcifications | Necrosis | Inflammation | ||||||||||||
Spine | L5S | 0.5 | SUS | Trajectory | 0 | 1 | 1 | 2 | 2 | 0 | 0 | 0 | 2 | 2 | 2 | 0 |
Screw head | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 2 | 2 | 2 | 0 | ||||
D5S | 0.5 | DD | Trajectory | Histology failed | ||||||||||||
Screw head | ||||||||||||||||
D25S | 2.5 | DD | Trajectory | 0 | 3 | 3 | 1 | 0 | 0 | 1 | 0 | 3 | 2 | 2 | 1 | |
Screw head | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 2 | 2 | 1 | 0 | ||||
L25S | 2.5 | SUS | Trajectory | 0 | 3 | 2 | 2 | 1 | 0 | 0 | 0 | 2 | 2 | 2 | 3 | |
Screw head | 0 | 3 | 1 | 2 | 1 | 0 | 0 | 0 | 2 | 2 | 2 | 3 | ||||
D50S | 5.0 | DD | Trajectory | 0 | 3 | 3 | 3 | 0 | 0 | 0 | 0 | 2 | 3 | 1 | 1 | |
Screw head | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 3 | 1 | 1 | ||||
L50S | 5.0 | SUS | Trajectory | 0 | 0 | 3 | 3 | 0 | 0 | 0 | 0 | 3 | 2 | 1 | 2 | |
Screw head | 0 | 0 | 2 | 1 | 0 | 0 | 0 | 0 | 2 | 1 | 1 | 0 | ||||
Femur | L5F | 0.5 | SUS | Trajectory | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | x | x | x | 3 |
Screw head | 0 | 3 | 1 | 1 | 0 | 0 | 0 | 0 | 3 | 2 | 2 | 1 | ||||
D5F | 0.5 | DD | Trajectory | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | x | x | x | x | |
Screw head | 0 | 2 | 1 | 0 | 0 | 0 | 1 | 3 | 3 | 3 | 1 | 3 | ||||
L25F | 2.5 | SUS | Trajectory | 0 | 2 | 0 | 1 | 2 | 0 | 1 | 0 | x | x | x | x | |
Screw head | 0 | 1 | 0 | 2 | 1 | 0 | 1 | 0 | 3 | 2 | 1 | 1 | ||||
D25F | 2.5 | DD | Trajectory | 0 | 2 | 1 | 1 | 0 | 0 | 0 | 0 | x | x | x | 1 | |
Screw head | 0 | 2 | 0 | 1 | 2 | 0 | 0 | 0 | 3 | 2 | 1 | 3 | ||||
L50F | 5.0 | SUS | Trajectory | 0 | 3 | 0 | 1 | 0 | 0 | 0 | 0 | x | x | x | 2 | |
Screw head | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 3 | 2 | 1 | 1 | ||||
D50F | 5.0 | DD | Trajectory | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | x | x | x | x | |
Screw head | 0 | 1 | 1 | 3 | 0 | 0 | 0 | 0 | 3 | 1 | 1 | 1 | ||||
L25F | 2.5 | SUS | Trajectory | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | x | x | x | 0 | |
Screw head | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 3 | 2 | 1 | 0 | ||||