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Table 3 F, female; IKDC, International Knee Documentation Committee; LM, lateral meniscus; M, male; MCL, medial collateral ligament; MM, medial meniscus; MRI, magnetic resonance imaging; PCL, posterior cruciate ligament; PKT, physio kinesitherapy. * Seven patients who underwent the Khalifa treatment showed a continuous unsuspected ACL on MRI at follow-up. ** Data referred to the 15 patients of the Khalifa treatment group

From: Spontaneous healing of a ruptured anterior cruciate ligament: a case series and literature review

First Author (Year)

Type of study

No. Of Patients (Mean Age) Sex

Type of Lesion

Associated Lesions

Activity Level

Follow-up months (range)

Rehabilitation type (duration months)

Failure rate (%)

KT -1000, mm

IKDC

Lysholm score

Healing definition

Ihara [28] (1994)

Prospective observational

25 + 7 PCL (23) 20 M / 12 F

/

24 LM 9 MM (6 LM + 1 MM for PCL lesions)

/

3

Kyuro knee brace (3) + Kinetec (0,5) + Dynamic joint control training (3) + Muscle strengthening exerces (3)+ No bearing (1) then partial bearing (0,5)

0 (0%)

/

/

/

Arthroscopy

Kurosaka [15] (1998)

Case Series

2 (18,5)

2 M / 0 F

(1) 1/3 proximal (0) midsubstance (1) 1/3 distal

1 MCL 1 MCL + MM

Competitive college sport participation

30 (24 to 36)

Double hinged brace. Unspecific rehabilitation protocol. (3-5).

0 (0%)

0,5 (range, 0-1)

/

/

Subjective Knee Function + Physical Examination + Arthroscopy

Malanga [16] (2001)

Case Report

1 (45) F

1/3 proximal

MCL

Dance instructor

19

No brace. No rehabilitation

0 (0%)

/

/

/

Physical Examination + Arthroscopy + RMI

Fujimoto [12] (2002)

Case Series

31 (33) 10 M / 21 F

/

0 meniscal lesions. No mention about other ligament.

Low athletic demand and sedentary occupation

16,1 (6 to 36)

Soft brace with 20-deg flexion block was applied for 3 months after the injury. Full weight-bearing withoutthe use of crutches was generally achieved within 4 weeks after the trauma. Jogging was started 5 months after surgery. (5)

8/31 (26%)

4

/

/

Subjective Knee Function + Physical Examination + MRI

Costa-Paz [11] (2012)

Case Series

14 (31) 12 M / 2 F

(8) 1/3 proximal; (6) mid-substance; (0) 1/3 distal

3 MM1 LL5 MCL

Recreational sport participation

25 (25 to 36)

No brace. Unspecific rehabilitationprotocol ( / )

2 had a reruptures (14%)1 had a meniscectomy (7%)

1,95 (Range 1-3,5)

10 Normal 4 Near normal

97 (range 90–100)

Subjective Knee Function + Physical Examination + MRI

Ofner [17] (2014)

Randomized Controlled Trial

30 (29,5) 14 M / 16 F

/

/

Recreational sport participation

• 1 group: Manual Khalifa Therapy + unspecific rehabilitation protocol (1,5)

• 1 group: unspecific rehabilitation protocol (1,5)

23/30 failures (76%) *

< 2 (Max 5mm) **

89,27 (SD 10,5) **

89,27 (SD 10,5) **

/

Subjective Knee Function + Physical Examination + MRI

Jacobi [7](2016)

Jacobi [7](2016)

Jacobi [7](2016)

/

0 ligament lesion No data about meniscal lesions

/

24

• 1 group: ACL-jack brace with range of motion 0-100° (4) then FKT

•. 1 group: No brace + PKT (2-4)

• 18/84 (21%) 13 failures + 5 reruptures • 6/20 (30%) failure

••••1,2 (± 2) 4,8 (± 2,5)

••••90 (± 8,7)

86.4 (± 11)

••••93.3 (± 8.3) 92.7 (± 7.4)

Subjective Knee Function + Physical Examination + MRI

Razi [10] (2021)

Case Series

15 (32) 8 M / 7 F

(15) 1/3 proximal (0) midsubstance (0) 1/3 distal

15 MCL (100%)2 Meniscus (13%)

Recreational sport participation

12

Brace for pain control + PKT ( / )

0 (0%)

/

/

/

Physical Examination + MRI