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Table 1 Risk of bias in included studies

From: Intra-articular injection of orthobiologics in patients undergoing high tibial osteotomy for knee osteoarthritis is safe and effective – a systematic review

RCTs

Random Sequence Generation

Allocation Concealment

Blinding of participants and personnel

Blinding of outcome assessment

Incomplete outcome data

Selective reporting

Other Bias

 

D’Elia et al, Revista Brasileira de Ortopedia 2015 [19]

Low Risk

Low Risk

Unclear Risk

Unclear Risk

Low Risk

Unclear Risk

Unclear Risk

 

Wong et al, Arthroscopy 2013 [20]

Low Risk

Low Risk

Low Risk

Unclear Risk

Low Risk

Low Risk

Unclear Risk

 

Koh et al, Arthroscopy 2014 [21]

Low Risk

Low Risk

Low Risk

Unclear Risk

Low Risk

Low Risk

High Risk

 

Non- RCTs

Confounding

Selection of Participants

Classification of interventions

Deviations from intended interventions

Missing Data

Measurement of outcomes

Selection of reported results

Overall ROB judgements

Magnanelli et al, Acta Biomedica 2020 [22]

Moderate

Moderate

Low

Low

Low

Low

Low

Moderate

Kim et al, American Journal of Sports Medicine 2018 [23]

Moderate

Moderate

Low

Low

Low

Low

Low

Moderate

Lee et al, Arthroscopy: The Journal of Arthroscopic and Related Surgery 2021 [24]

Moderate

Moderate

Low

Low

Low

Low

Low

Moderate

Jin et al, Knee Surgery, Sports Traumatology, Arthroscopy 2021 [15]

Moderate

Moderate

Low

Low

Low

Low

Low

Moderate

Yang et al, Knee Surgery, Sports Traumatology, Arthroscopy 2021 [25]

Moderate

Low

Low

Low

Low

Low

Low

Moderate