Table 2 Use of photopolymerizable hydrogels in vivo for applications in cartilage research

PEODA/HA^a,b

–

UV

–

7

4–5

hBMSCs

rabbit (full-thickness chondral defects)

4 weeks

Cartilage repair after 28 days, enhanced cellularity of de novo tissues that filled the defects

(Dua et al., 2016)

MeHA^b

–

UV

360

–

1.2

rat BMSCs

mice (full-thickness chondral defects)

8 weeks

MeHA is biocompatible and osteoconductive, no sign of chondrocyte aggregation in the defects

(Lin et al., 2017)

mGL/MHA^b

–

VL

430–490

4

1400

hBMSCs

rabbit (full-thickness osteochondral defects)

12 weeks

MSC chondrogenesis, optimal cartilage and bone formation using mGL/MHA at 9:1

(Lin et al., 2019)

PEG/MMP-2^b

–

VL

352

8

5

rabbit BMSCs

rabbit (full-thickness osteochondral defects)

24 weeks

MSC chondrogenesis in vivo

(Pascual-Garrido et al., 2019)

PEODA/HA^b

–

UV

365

5

6–8

–

rabbit (full-thickness chondral defects)

5 weeks

Cartilage repair

(Ramaswamy et al., 2008b)

PEG/PCL^a

–

VL

450

1

1000

human chondrocytes

rat (s.c.)

4 weeks

ECM deposition (type-II and -VI collagen, GAGs), cartilage repair

(Werkmeister et al., 2010)

PEODA/HA^b

TGF-β3

UV

365

10

4

hBMSCs

mouse (s.c.)

3 weeks

Chondrogenic differentiation

(Sharma et al., 2007)