Fig. 2

Upper extremity functional assessment following per-elbow soft tissue injury. To assess changes in upper extremity function in our model following injury with or without an investigator induce plasminogen (PLG) deficiency, a Treadscan analysis was utilized to measure active motion in longitudinal direction. Points (n) represent individual limbs, left and right per mouse. N = 7; uninjured controls, 7; Injury + Control ASO, 7; Injury + PLG ASO. n = 14 points per group. Mean ± SD: Uninjured control- 35.05 ± 2.776; Muscle Injury + Control ASO- 32.20 ± 3.294; Muscle Injury + PLG ASO- 29.87 ± 2.075. b Grip strength analysis plotted as an average per mouse. N = 7; uninjured controls, 7; Injury + Control ASO, 7; Injury + PLG ASO. Total of 7 data points per group. Mean ± SD: Uninjured control- 2.387 ± 0.136; Muscle Injury + Control ASO- 2.238 ± 0.076; Muscle Injury + PLG ASO- 1.921 ± 0.157. Data represented in all plots as mean +/− SD. Statistical difference was assessed by an ordinary two-way ANOVA with a Tukey’s multiple comparison test. P values reported are adjusted for multiplicity