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Table 1 Characteristics across study period

From: Tacrolimus as an adjunct to autologous minced muscle grafts for the repair of a volumetric muscle loss injury

 

Sham

VML

VML + MMG

VML + Tacrolimus

VML + MMG + Tacrolimus

n=

1

2

4

Body mass (kg)

 Week 0

39.4 ± 0.0

41.9 ± 2.3

41.7 ± 0.8

 Week 4

48.6 ± 0.0

49.9 ± 3.1

46.5 ± 0.7

 Week 8

54.2 ± 0.0

56.6 ± 2.8

51.8 ± 2.8

 Week 12

61.2 ± 0.0

65.3 ± 3.9

55.7 ± 3.3

Tacrolimus concentration (ng/ml)

 Day 3

nd

nd

1.12 ± 0.29

 Day 9

nd

nd

1.35 ± 0.14

 Week 2

nd

nd

1.73 ± 0.25

 Week 3

nd

nd

2.26 ± 0.65

 Week 4

nd

nd

3.25 ± 1.58

 Week 6

nd

nd

nd

  1. Circulating levels of tacrolimus were analyzed; levels were non-detectible (nd) in the untreated and sham animals and 2 weeks following termination of treatment
  2. Mean ± standard error
  3. VML volumetric muscle loss, MMG minced muscle graft