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Table 2 Invasive and non-invasive models

From: Basic science of osteoarthritis

  Invasive models Non-invasive models
Advantages rapid induction, high reproducibility, readily available, widely described systems rapid induction, high reproducibility, low infection risk, long time frame of OA changes, allowing for early evaluation and intervention
Limitations risk of infection, expertise needed, early changes often, undetectable because of rapid induction not readily available, expertise needed, scarce literature