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Journal of Experimental Orthopaedics
Fig. 1 | Journal of Experimental Orthopaedics

Fig. 1

From: Intra-articular interleukin-1 receptor antagonist (IL1-ra) microspheres for posttraumatic osteoarthritis: in vitro biological activity and in vivo disease modifying effect

Fig. 1

IL-1 ra containing PLGA microspheres. a, b Representative scanning electron micrographs of PLGA IL-1 ra microspheres at different magnifications. c Release of IL-1ra from PLGA-IL1 ra microspheres over time. Cumulative IL-1 ra release at 72 h was significantly higher than cumulative release at 6, 12, 24 and 48 h. Similarly, cumulative IL-1 ra release at 24 and 48 h was significantly higher than cumulative release at 6 and 12 h, respectively. *p < 0.001. Data represents the average ± SD of 4 different preparations

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