White blood cell concentration correlates with increased concentrations of IL-1ra and improvement in WOMAC pain scores in an open-label safety study of autologous protein solution

Journal of Experimental Orthopaedics

Table 5 Coefficient of correlation values (R²) of whole blood and APS metrics with WOMAC Pain scores

Metric	Solution	WOMAC Pain-Injection Visit	WOMAC Pain-1 Week	WOMAC Pain-6 Months
WBC Concentration	Whole Blood	0.43	0.42	0.24
WBC Concentration	APS	0.01	0.58	0.22
IL-1ra:IL-1β Ratio	Whole Blood	0.02	0.64	0.47
IL-1ra:IL-1β Ratio	APS	0.01	0.37	0.46
IL-1ra	Whole Blood	0.04	0.30	0.53
IL-1ra	APS	0.02	0.52	0.10
sIL-1RII	Whole Blood	0.19	<0.01	0.02
sIL-1RII	APS	0.03	0.32	0.30
IL-1β	Whole Blood	0.01	0.09	0.19
IL-1β	APS	0.02	0.04	0.46
sTNF-RII	Whole Blood	0.02	0.16	0.37
sTNF-RII	APS	0.04	0.26	0.52
TNFα	Whole Blood	<0.01	0.20	0.38
TNFα	APS	0.02	0.39	0.35
Injection Volume	APS	0.03	0.01	0.02

*Bold font represents (p < 0.05) and improved pain scores and italicized and underlined font represent significant and diminished pain scores with significant correlation (n > 8)