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Table 5 Coefficient of correlation values (R2) of whole blood and APS metrics with WOMAC Pain scores

From: White blood cell concentration correlates with increased concentrations of IL-1ra and improvement in WOMAC pain scores in an open-label safety study of autologous protein solution

Metric Solution WOMAC Pain-Injection Visit WOMAC Pain-1 Week WOMAC Pain-6 Months
WBC Concentration Whole Blood 0.43 0.42 0.24
APS 0.01 0.58 0.22
IL-1ra:IL-1β Ratio Whole Blood 0.02 0.64 0.47
APS 0.01 0.37 0.46
IL-1ra Whole Blood 0.04 0.30 0.53
APS 0.02 0.52 0.10
sIL-1RII Whole Blood 0.19 <0.01 0.02
APS 0.03 0.32 0.30
IL-1β Whole Blood 0.01 0.09 0.19
APS 0.02 0.04 0.46
sTNF-RII Whole Blood 0.02 0.16 0.37
APS 0.04 0.26 0.52
TNFα Whole Blood <0.01 0.20 0.38
APS 0.02 0.39 0.35
Injection Volume APS 0.03 0.01 0.02
  1. *Bold font represents (p < 0.05) and improved pain scores and italicized and underlined font represent significant and diminished pain scores with significant correlation (n > 8)