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Table 3 Average concentrations of cytokines in whole blood and APS. (average ± standard deviation, n = 9)

From: White blood cell concentration correlates with increased concentrations of IL-1ra and improvement in WOMAC pain scores in an open-label safety study of autologous protein solution

Metric

IL-1ra

sIL-1RII

IL-1β

sTNF-RII

TNFα

Whole Blood Concentration (pg/ml)

8,029 ± 2,818

6,798 ± 1,623

1.6 ± 0.9

1,036 ± 188

0.7 ± 1.2

APS Concentration (pg/ml)

57,511 ± 24,272

20,121 ± 6,654

20.3 ± 34.2

5,520 ± 1,174

2.6 ± 2.9

Blood Concentration Range (pg/ml)

3,450–11,750

4,622–9,050

0.7–3.3

891–1,563

0.0–3.4

APS Concentration Range (pg/ml)

23,100–97,750

11,350–28,155

2.8–109.3

3,934–7,556

0–7.5

p values

6.8E–05

2.0E–05

0.07

6.2E–07

0.02