Skip to main content
Journal of Experimental Orthopaedics

Table 1 Levels of biomarkers and volume in SF before the first HA injection (week 0) and fifth injection (week 5)

From: Changes in synovial fluid biomarkers and clinical efficacy of intra-articular injections of hyaluronic acid for patients with knee osteoarthritis

 

Week 0

Week 5

Pvalue

HA (mg/ml)

1.48 ± 0.40

1.72 ± 0.36

<0.001

C6S (nmol/ml)

62.2 ± 30.4

49.6 ± 18.4

0.001

C4S (nmol/ml)

18.2 ± 6.3

15.9 ± 4.6

0.001

KS (μg/ml)

6.68 ± 4.25

6.18 ± 3.81

0.172

IL-6 (pg/ml)

3458 ± 9094

486 ± 1294

0.013

Viscosity (mPa · S)

48.1 ± 26.7

67.8 ± 35.2

<0.001

SF (ml)

15.9 ± 12.5

8.2 ± 8.7

<0.001

  1. SF: synovial fluid. HA: hyaluronic acid. C6S: chondroitin 6-sulfate. C4S: chondroitin 4-sulfate. KS: keratin sulfate. IL-6: interleukin-6.
  2. Data are given as mean ± standard deviation.
Back to article page