Empty defect | Scaffold only | rhFGF18 | BMP-7 | ||||||
---|---|---|---|---|---|---|---|---|---|
MFC | LTS | MFC | LTS | MFC | LTS | MFC | LTS | ||
I | % Hyaline Cartilage: | 0.80 | 1.00 | 1.00 | 1.67 | 3.00 | 2.00 | 1.33 | 0.00 |
II | Structural Characteristics: | ||||||||
A. Surface Irregularity: | 0.20 | 0.75 | 1.17 | 1.83 | 1.83 | 1.33 | 0.67 | 0.83 | |
B. Structural integrity: | 0.40 | 0.50 | 0.67 | 1.00 | 1.17 | 0.50 | 0.83 | 0.50 | |
C. Thickness: | 0.80 | 0.75 | 0.83 | 0.83 | 1.33 | 0.67 | 1.00 | 0.33 | |
D. Bonding to adjacent cartilage: | 1.20 | 1.00 | 2.00 | 1.50 | 1.83 | 1.67 | 2.00 | 1.17 | |
III | Freedom from cellular changes of degeneration: | 0.60 | 0.25 | 0.67 | 1.00 | 0.83 | 0.83 | 1.00 | 0.50 |
IV | Freedom from degenerate changes in adjacent cartilage: | 1.80 | 1.75 | 2.17 | 1.50 | 2.33 | 2.33 | 2.50 | 2.33 |
V | Reconstitution of subchondral bone: | 1.00 | 0.75 | 0.33 | 0.67 | 0.67 | 0.83 | 1.17 | 0.50 |
VI | Bonding of repair cartilage to denovo subchondral bone: | 1.60 | 1.00 | 1.33 | 1.67 | 1.83 | 1.67 | 2.00 | 1.33 |
VII | Safranin O: | 0.60 | 0.50 | 1.00 | 1.00 | 2.00 | 1.33 | 1.50 | 0.33 |
MEAN TOTAL SCORE | 9.00 | 8.25 | 11.17 | 12.70 | 16.83 | 13.20 | 14.00 | 7.83 | |
p < 0.05 | * | * |