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Figure 4 | Journal of Experimental Orthopaedics

Figure 4

From: Osteochondral tissue engineering using a biphasic collagen/GAG scaffold containing rhFGF18 or BMP-7 in an ovine model

Figure 4

Histological sections stained with Safranin O. A) Empty defect, B) Scaffold alone, C) Scaffold + rhFGF-18, D) Scaffold + BMP-7. In A, B and C there is good tissue fill. Differences in subchondral bone formation can be observed. The empty defect A shows subchondral hypertrophy, whilst in C and D there appears to be a cartilage cleft, with significant proteoglycan staining extending down into the subchondral bone. In D there is a large subchondral cyst. The arrows denote the margins of the defect.

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