Table 1 Sequence termini on cleavage fragments of human aggrecan for which anti-neoepitope antibody reactivity, or direct sequencing, have demonstrated the presence of specific products in vivo

IGD

DIPEN³⁶⁰

MMP

(Flannery et al. [1992])

³⁶¹FFGVG

MMP

(Fosang et al. [1995])

ITVQTV³⁷⁵

HtrA1

(Chamberland et al. [2009])

ITEGE³⁹²

ADAMTS4/5

(Lark et al. [1997])

³⁹³ARGSV

ADAMTS4/5

(Sandy et al. [1992])

KS-rich

VPGVA⁷⁰⁹

Calpain

(Maehara et al. [2007])

CS1

VGDLS⁹⁵⁴

Calpain

(Struglics et al. [2006])

CS2

ASELE¹⁵⁶⁴

ADAMTS4/5

(Sandy and Verscharen, [2001])

FKEEE¹⁷³³

ADAMTS4/5

(Sandy and Verscharen, [2001])

¹⁸³⁸AGEGP

ADAMTS4/5

(Dufield et al. [2010])

¹⁹³⁹LGQRP

ADAMTS4/5

(Sandy and Verscharen, [2001])