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Journal of Experimental Orthopaedics
Fig. 4 | Journal of Experimental Orthopaedics

Fig. 4

From: Lack of concentration-dependent local toxicity of highly concentrated (5%) versus conventional 0.5% bupivacaine following musculoskeletal surgery in a rat model

Fig. 4

Body weight changes in rats undergoing surgery and infusion of bupivacaine. Median body weight and interquartile range (IQR) are shown. (i) Weight changes over time in rats receiving bupivacaine infusion in a dose-dump or sustained fashion. (ii) Weight changes over time in rats undergoing spinal or femoral catheter implantation and bupivacaine infusion. (iii) Weight changes over time in rats receiving infusion of 0.5%, 2.5%, or 5.0% bupivacaine HCl solution. T = 0 marks preoperative weight

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