Marker | Function(s) | Reference(s) |
---|---|---|
Scleraxis (SCX) | Transcriptional activator that regulates the expression of tenomodulin and the proliferation of tenocytes | |
Tenomodulin (TNMD) | A transmembrane glycoprotein, a specific marker of mature tendons and ligaments that has anti-angiogenic activity and promotes the maturation and maintenance of the differentiated tendon phenotype | |
Tenascin-C (TNC) | A glycoprotein known to be present in healthy tendon and is involved in the regulation of collagen fibrillogenesis | [38] |
Type I Collagen (COL1A1) | The most abundant molecule in the tendon extracellular matrix | |
Type III Collagen (COL3A1) | The 2nd most abundant collagen in tendon, and its expression is stimulated during tendon repair | |
Decorin (DCN) | Necessary for maintaining collagen fibril integrity in mature tendon | [39] |