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Table 1 Markers of tenocyte phenotype. Tenocyte phenotypic markers, their associated functions, and references are provided

From: A decellularized flowable placental connective tissue matrix supports cellular functions of human tenocytes in vitro

Marker

Function(s)

Reference(s)

Scleraxis (SCX)

Transcriptional activator that regulates the expression of tenomodulin and the proliferation of tenocytes

[31, 43]

Tenomodulin (TNMD)

A transmembrane glycoprotein, a specific marker of mature tendons and ligaments that has anti-angiogenic activity and promotes the maturation and maintenance of the differentiated tendon phenotype

[21, 44]

Tenascin-C (TNC)

A glycoprotein known to be present in healthy tendon and is involved in the regulation of collagen fibrillogenesis

[38]

Type I Collagen (COL1A1)

The most abundant molecule in the tendon extracellular matrix

[10, 42]

Type III Collagen (COL3A1)

The 2nd most abundant collagen in tendon, and its expression is stimulated during tendon repair

[10, 42]

Decorin (DCN)

Necessary for maintaining collagen fibril integrity in mature tendon

[39]