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Journal of Experimental Orthopaedics
Fig. 5 | Journal of Experimental Orthopaedics

Fig. 5

From: Neutralization of HMGB1 improves fracture healing and γδ T lymphocyte counts at the fracture site in a polytrauma rat model

Fig. 5

Immunophenotyping of immune cells in the fracture site at 1 week post-trauma (wpt) in osteotomy rats (OST), polytrauma rats (PT-C), PT rats with chicken IgY isotype (PT-IgY), and PT rats with anti-HMGB1 (PT-Ab HMGB1) rats. Frequencies of A CD3+ T cells in total; B CD3+CD4+ T cells; C CD3+CD8+ T cells; D CD3+γδ TCR+ T cells; E CD3+CD4+CD8+ T cells, all within the CD3+ T cells’ pool in OST, PT-C, PT-IgY and PT-Ab HMGB1 rats (n = 4–5/group). Bone marrow cells from naïve uninjured rats were used as baseline controls (n = 4) (dotted line). * p < 0.05 comparing OST, PT-IgY, PT-Ab HMGB1 and PT-C cell percentages. Data are graphically represented as mean ± SEM

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