Skip to main content
Fig. 2 | Journal of Experimental Orthopaedics

Fig. 2

From: Neutralization of HMGB1 improves fracture healing and γδ T lymphocyte counts at the fracture site in a polytrauma rat model

Fig. 2

Micro-computed tomography (μCT) analysis indicates improved bone regeneration in PT following neutralization of extracellular HMGB1. (A) Representative radiographs at 5 weeks post-trauma (wpt); a) Osteotomy, b) Polytrauma, c) Polytrauma + AbHMGB1 (n = 10–11/group). (B) Representation of the two VOIs analyzed depicting the space in which the excised bone used to be i.e., ‘Defect’ and the volume in which any new callus has formed i.e., ‘Continuous Callus’. (C) Bone Volume (mm^3) results from the Defect VOI; (D) Bone Volume Fraction (%) results from the Defect VOI; (E) Bone Volume (mm^3) results from the Continuous Callus VOI; (F) Bone Volume Fraction (%) results from the Continuous Callus VOI. * p < 0.05 versus corresponding non-treated PT-C group. Data are graphically represented as mean ± SEM

Back to article page