First Author, Year | Study Type | Procedural Details | PRP + HA composition (ml) | PRP Composition (ml) | Number of injections | Injection Interval (weeks) |
---|---|---|---|---|---|---|
Ding, 2017 [12] | RCT | PRP: 40 ml venous blood added to sodium citrate; centrifuged for 10 min at 1450 rpm; PCP aspirated and transferred out, then centrifuged for 10 min at 3370 rpm; yield 5 ml PRP HA: 25 mg/2.5 ml PRP and HA administered together | PRP: 4 HA: 2.5 | 4 | 3 | 1 |
Zhao, 2018 [45] | RCT | PRP: 5 ml whole blood centrifuged to obtain PRP PRP and HA administered together | PRP: 4 HA: 2.5 | 2 | 5 | 1 |
Ke, 2016 [22] | RCT | PRP: 40 ml venous blood added to 4 ml of sodium citrate; centrifuged for 10 min at 1500 rpm; PCP aspirated and transferred out, then centrifuged for 10 min at 1500 rpm; activation with 0.2 ml of calcium chloride; yield 4 ml PRP PRP administered first, HA 10 min later | PRP: 4 HA: 2 | 6 | 5 | 1 |
Guo, 2018 [17] | RCT | PRP: 45 ml blood added to 5 ml of citrate phosphate dextrose; centrifuged for 10 min at 2000 rpm; PCP aspirated and transferred out, then centrifuged for 10 min at 2200 rpm; yield 7 ml PRP PRP and HA administered together | PRP: 3.5 HA: 2 | 3.5 | 3 | 1 |
Abate, 2015 [1] | Retrospective cohort | PRP+ HA: 4 ml blood added to 2 ml HA (natural, non-crosslinked, fermented, 1550 kDa, 40 mg); centrifuged for 5 min at 3500 rpm; yield 2 ml of PRP + 2 ml of HA PRP: 8 ml blood centrifuged for 5 min at 3500 rpm; yield 4-5 ml PRP and HA administered together | PRP: 2 HA: 2 | 4–5 | 3 | 1 |
Guo, 2016 [18] | Retrospective cohort | NS PRP and HA administered together | PRP: NS HA: NS | NS | 3 | 1 |
Jacob, 2017 [21] | RCT | PRP: 20-ml venous blood added to 5-ml of citrate phosphate dextrose; centrifuged for 7 min at 3500 rpm; PCP aspirated and transferred out, then centrifuged for 5 min at 3000 rpm; yield 2.5 ml PRP Administration details NS | PRP: NS HA: NS | 2 | NS | NS |
Yu, 2018 [42] | RCT | PRP: Plasma samples were prepared immediately using centrifugation at 2000 g at 4 °C for 10 min PRP and HA administered together | PRP: 8 HA: 0.2 mg | 8 | 8 | 1 |
Palco, 2021 [28] | Retrospective cohort | PRP + HA: CellularMatrix A-CP-HA used; 8-ml of venous blood centrifuged for 5 min at 3400 rpm/1500 g; yield 3 ml PRP; Platelet concentration: 290 k platelets/mm3 L-PRP: RegenKit-THT-3/RegenCell used; 8-ml of venous blood centrifuged for 9 min at 3400 rpm/1500 g; yield 5 ml PRP; Platelet concentration: 340 k platelets/mm3 Administration details NS | PRP: 3 HA: 2 | 5 | NS | NS |
Sun, 2021 [37] | RCT | PRP: 7-mL of venous blood collected in PLTenus PLUS Platelet Concentrate Separator; centrifuged at 500-1200 rpm for 8 min; yield 3 ml LP-PRP; Average platelet count: 463.83 ± 75.39 × 103/ul HA: HYAJOINT Plus; cross-linked with BDDE 3 ml of HA injected first, then 3 ml of PRP | PRP: 3 HA: 3 | 3 | 1 | NS |