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Table 2 detailing the details of the administration and composition of PRP + HA and PRP alone of the included studies. NS = not specified

From: Comparing the efficacy of dual Platelet-Rich Plasma (PRP) and Hyaluronic Acid (HA) therapy with PRP-alone therapy in the treatment of knee osteoarthritis: a systematic review and meta-analysis

First Author, Year Study Type Procedural Details PRP + HA composition (ml) PRP
Composition (ml)
Number of injections Injection Interval (weeks)
Ding, 2017 [12] RCT PRP: 40 ml venous blood added to sodium citrate; centrifuged for 10 min at 1450 rpm; PCP aspirated and transferred out, then centrifuged for 10 min at 3370 rpm; yield 5 ml PRP
HA: 25 mg/2.5 ml
PRP and HA administered together
PRP: 4
HA: 2.5
4 3 1
Zhao, 2018 [45] RCT PRP: 5 ml whole blood centrifuged to obtain PRP
PRP and HA administered together
PRP: 4
HA: 2.5
2 5 1
Ke,
2016 [22]
RCT PRP: 40 ml venous blood added to 4 ml of sodium citrate; centrifuged for 10 min at 1500 rpm; PCP aspirated and transferred out, then centrifuged for 10 min at 1500 rpm; activation with 0.2 ml of calcium chloride; yield 4 ml PRP
PRP administered first, HA 10 min later
PRP: 4
HA: 2
6 5 1
Guo, 2018 [17] RCT PRP: 45 ml blood added to 5 ml of citrate phosphate dextrose; centrifuged for 10 min at 2000 rpm; PCP aspirated and transferred out, then centrifuged for 10 min at 2200 rpm; yield 7 ml PRP
PRP and HA administered together
PRP: 3.5
HA: 2
3.5 3 1
Abate, 2015 [1] Retrospective cohort PRP+ HA: 4 ml blood added to 2 ml HA (natural, non-crosslinked, fermented, 1550 kDa, 40 mg); centrifuged for 5 min at 3500 rpm; yield 2 ml of PRP + 2 ml of HA
PRP: 8 ml blood centrifuged for 5 min at 3500 rpm; yield 4-5 ml
PRP and HA administered together
PRP: 2
HA: 2
4–5 3 1
Guo, 2016 [18] Retrospective cohort NS
PRP and HA administered together
PRP: NS
HA: NS
NS 3 1
Jacob, 2017 [21] RCT PRP: 20-ml venous blood added to 5-ml of citrate phosphate dextrose; centrifuged for 7 min at 3500 rpm; PCP aspirated and transferred out, then centrifuged for 5 min at 3000 rpm; yield 2.5 ml PRP
Administration details NS
PRP: NS
HA: NS
2 NS NS
Yu,
2018 [42]
RCT PRP: Plasma samples were prepared immediately using centrifugation at 2000 g at 4 °C for 10 min
PRP and HA administered together
PRP: 8
HA: 0.2 mg
8 8 1
Palco, 2021 [28] Retrospective
cohort
PRP + HA: CellularMatrix A-CP-HA used; 8-ml of venous blood centrifuged for 5 min at 3400 rpm/1500 g; yield 3 ml PRP; Platelet concentration: 290 k platelets/mm3
L-PRP: RegenKit-THT-3/RegenCell used; 8-ml of venous blood centrifuged for 9 min at 3400 rpm/1500 g; yield 5 ml PRP; Platelet concentration: 340 k platelets/mm3
Administration details NS
PRP: 3
HA: 2
5 NS NS
Sun, 2021 [37] RCT PRP: 7-mL of venous blood collected in PLTenus PLUS Platelet Concentrate Separator; centrifuged at 500-1200 rpm for 8 min; yield 3 ml LP-PRP; Average platelet count: 463.83 ± 75.39 × 103/ul
HA: HYAJOINT Plus; cross-linked with BDDE
3 ml of HA injected first, then 3 ml of PRP
PRP: 3
HA: 3
3 1 NS