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Table 2 detailing the details of the administration and composition of PRP + HA and PRP alone of the included studies. NS = not specified

From: Comparing the efficacy of dual Platelet-Rich Plasma (PRP) and Hyaluronic Acid (HA) therapy with PRP-alone therapy in the treatment of knee osteoarthritis: a systematic review and meta-analysis

First Author, Year

Study Type

Procedural Details

PRP + HA composition (ml)

PRP

Composition (ml)

Number of injections

Injection Interval (weeks)

Ding, 2017 [12]

RCT

PRP: 40 ml venous blood added to sodium citrate; centrifuged for 10 min at 1450 rpm; PCP aspirated and transferred out, then centrifuged for 10 min at 3370 rpm; yield 5 ml PRP

HA: 25 mg/2.5 ml

PRP and HA administered together

PRP: 4

HA: 2.5

4

3

1

Zhao, 2018 [45]

RCT

PRP: 5 ml whole blood centrifuged to obtain PRP

PRP and HA administered together

PRP: 4

HA: 2.5

2

5

1

Ke,

2016 [22]

RCT

PRP: 40 ml venous blood added to 4 ml of sodium citrate; centrifuged for 10 min at 1500 rpm; PCP aspirated and transferred out, then centrifuged for 10 min at 1500 rpm; activation with 0.2 ml of calcium chloride; yield 4 ml PRP

PRP administered first, HA 10 min later

PRP: 4

HA: 2

6

5

1

Guo, 2018 [17]

RCT

PRP: 45 ml blood added to 5 ml of citrate phosphate dextrose; centrifuged for 10 min at 2000 rpm; PCP aspirated and transferred out, then centrifuged for 10 min at 2200 rpm; yield 7 ml PRP

PRP and HA administered together

PRP: 3.5

HA: 2

3.5

3

1

Abate, 2015 [1]

Retrospective cohort

PRP+ HA: 4 ml blood added to 2 ml HA (natural, non-crosslinked, fermented, 1550 kDa, 40 mg); centrifuged for 5 min at 3500 rpm; yield 2 ml of PRP + 2 ml of HA

PRP: 8 ml blood centrifuged for 5 min at 3500 rpm; yield 4-5 ml

PRP and HA administered together

PRP: 2

HA: 2

4–5

3

1

Guo, 2016 [18]

Retrospective cohort

NS

PRP and HA administered together

PRP: NS

HA: NS

NS

3

1

Jacob, 2017 [21]

RCT

PRP: 20-ml venous blood added to 5-ml of citrate phosphate dextrose; centrifuged for 7 min at 3500 rpm; PCP aspirated and transferred out, then centrifuged for 5 min at 3000 rpm; yield 2.5 ml PRP

Administration details NS

PRP: NS

HA: NS

2

NS

NS

Yu,

2018 [42]

RCT

PRP: Plasma samples were prepared immediately using centrifugation at 2000 g at 4 °C for 10 min

PRP and HA administered together

PRP: 8

HA: 0.2 mg

8

8

1

Palco, 2021 [28]

Retrospective

cohort

PRP + HA: CellularMatrix A-CP-HA used; 8-ml of venous blood centrifuged for 5 min at 3400 rpm/1500 g; yield 3 ml PRP; Platelet concentration: 290 k platelets/mm3

L-PRP: RegenKit-THT-3/RegenCell used; 8-ml of venous blood centrifuged for 9 min at 3400 rpm/1500 g; yield 5 ml PRP; Platelet concentration: 340 k platelets/mm3

Administration details NS

PRP: 3

HA: 2

5

NS

NS

Sun, 2021 [37]

RCT

PRP: 7-mL of venous blood collected in PLTenus PLUS Platelet Concentrate Separator; centrifuged at 500-1200 rpm for 8 min; yield 3 ml LP-PRP; Average platelet count: 463.83 ± 75.39 × 103/ul

HA: HYAJOINT Plus; cross-linked with BDDE

3 ml of HA injected first, then 3 ml of PRP

PRP: 3

HA: 3

3

1

NS