Study | Type of Osteotomy Performed | Intervention | Number of Patients in Intervention Group | Number of Patients in Control Group | Number of Patients undergoing second-look Arthroscopy | Pre-OP Koshino Staging | Post-OP Koshino Staging | Pre-OP ICRS-CRA | Post-OP ICRS-CRA | Pre-OP IKDC Score | Post-OP IKDC Score | Pre-OP WOMAC Score | Post-OP WOMAC score |
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Jin et al, Knee Surgery, Sports Traumatology, Arthroscopy 2021 [15] | HTO | Microfracture with BMAC | 48 | 43 | 64/91 at mean 2 years post-op | Not Reported | Group I (n = 31) vs Group II (n = 33): Regeneration Stage: Stage A: 5 (16.1%) v 2 (6.1%) Stage B: 16 (51.6%) v 15 (45.5%) Stage C-1: 9 (29.0%) v 14 (42.4%) Stage C-2: 1 (3.2%) v 2 (6.1%) | Group I (n = 43) v Group II (n = 48) Grade III: 38 v 41 Grade IV: 5 v 7 | Group I (n = 31) vs Group II (n = 33) Grade I: 0 v 1 Grade II: 12 v 18 Grade III: 10 v 11 | Group I (n = 43) v Group II (n = 48): 33.7 ± 9.4 vs 35.3 ± 12.6 | Group I (n = 43) v Group II (n = 48): At 1 year: 67.0 ± 10.6 vs 71.3 ± 11.2 | Group I (n = 43) vs II (n = 48) 47.5 ± 10.4 vs 46.9 ± 13.9 | Group I (n = 43) vs II (n = 48) 20.4 ± 9.7 vs 16.3 ± 9.8 |
Yang et al, Knee Surgery, Sports Traumatology, Arthroscopy 2021 [25] | HTO | BMAC (55 Patients) hUCB-MSCs (55 Patients) | 110 | N.A | 81/110 at mean 17 months post-op | Not Reported | BMAC (n = 37) v hUCB-MSC (n = 44) Stage A: 4 (10.8%) v 0 (0%) Stage B: 12 (32.4%) v 12 (27.3%) Stage C: 21 (56.8%) v 32 (72.7%) | BMAC (n = 55) vs hUBC-MSC (n = 55) Grade III: 5v3 Grade IV: 50 v 52 | BMAC (n = 37) v hUBC-MSC (n = 44) Grade I: 1 v 4 Grade II: 20 v 30 Grade III: 11 v 10 Grade IV: 5 v 0 | BMAC (n = 55) v hUCB-MSC (n = 55) 36.2 ± 3.0 v 35.4 ± 5.5 | BMAC (n = 55) v hUCB-MSC (n = 55) At latest follow-up (mean 33.0 months): 72.8 ± 5.8 v 73.3 ± 9.8 | Not Reported | Not reported |
Lee et al, Arthroscopy: The Journal of Arthroscopic and Related Surgery 2021 [24] | HTO | BMAC (42 Patients) hUCB-MSCs (32 Patients) | 74 | N.A | 74/74 after minimum 1 year post-op | Not Reported | Not reported | Not Reported | BMAC (n = 42 Patients) v hUCB-MSC (n = 32 Patients)I: 1 v 6 II: 18 v 20 III: 12 v 6 IV: 11 v 0 | Not reported | Not Reported | BMAC (n = 42 Patients) v hUCB-MSC (n = 32 Patients)43.9 ± 12.7 v 45.2 ± 8.8 | BMAC (n = 42 Patients) v hUCB-MSC (n = 32 Patients) At latest follow-up:23.4 ± 11.6 v 19.5 ± 15.58 |
D’Elia et al, Revista Brasileira de Ortopedia 2015 [19] | HTO | PRP with BMAC | 11 | 14 | N.A | Not Reported | Not Reported | Not Reported | Not Reported | Not Reported | Not Reported | Not Reported | Not Reported |
Study | Pre-OP KSS Score | Post-OP KSS Score | Pre-OP KOOS Score | Post-OP KOOS Score | Pre-OP SF-36 Score | Post-OP SF-36 Score | Pre-OP Tegner Activity Scale | Post-OP Tegner Activity Scale | Pre-OP HSS Score | Post-OP HSS Score | Pre-OP VAS | Post-OP VAS |
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Jin et al, Knee Surgery, Sports Traumatology, Arthroscopy 2021 [15] | Group I (n = 43) vs II (n = 48) Pain Subscale: 27.0 ± 8.5 vs 27.2 ± 7.6 Function Subscale: 60.6 ± 11.0 vs 58.9 ± 13.3 | Group I (n = 43) vs II (n = 48) At Final followup (Mean 22.8 months for Group I and 20.3 months for Group II) Pain Subscale: 39.7 ± 6.5 vs 42.6 ± 7.2 Function Subscale: 88.8 ± 8.2 vs 91.0 ± 10.2 | Not Reported | Not Reported | Not Reported | Not Reported | Not Reported | Not Reported | Not Reported | Not Reported | Not Reported | Not Reported |
Yang et al, Knee Surgery, Sports Traumatology, Arthroscopy 2021 [25] | Not Reported | Not Reported | BMAC (n = 55) v hUBC (n = 55) 1)Pain: 42.3 ± 3.7 v 41.4 ± 6.5 2)Symptoms:40.9 ± 5.1 v 39.5 ± 6.9 3)ADL 52.0 ± 7.1 v 51.5 ± 8.4 4)Sports and rec 23.8 ± 7.0 v 23.7 ± 9.2 5)QOL 31.1 ± 4.8 v 29.8 ± 6.3 | BMAC (n = 55) v hUBC (n = 55) At latest follow-up (mean 33.0 months): 1)Pain: 81.7 ± 6.4 v 83.1 ± 8.3 2)Symptoms: 79.2 ± 7.5 v 79.4 ± 8.8 3)ADL: 82.4 ± 5.0 v 83.1 ± 5.8 4)Sports and rec: 62.0 ± 11.9 v 63.2 ± 10.7 5)QOL: 72.4 ± 6.8 v 73.8 ± 8.7 | BMAC (n = 55) v hUBC (n = 55) Physical Component: 42.2 ± 3.5 v 41.5 ± 5.5 Mental Component: 57.2 ± 8.0 v 57.0 ± 9.2 | BMAC (n = 55) v hUBC (n = 55) At latest follow-up (mean 33.0 months) Physical Component: 64.7 ± 5.9 v 65.4 ± 7.9Mental Component: 64.0 ± 8.7 v 64.7 ± 8.8 | BMAC (n = 55) v hUBC (n = 55) 2.3 ± 0.9 v 2.2 ± 0.8 | BMAC (n = 55) v hUBC (n = 55) At latest follow-up (mean 33.0 months) 4.0 ± 0.5 v 4.1 ± 0.5 | Not Reported | Not Reported | Not Reported | Not Reported |
Lee et al, Arthroscopy: The Journal of Arthroscopic and Related Surgery 2021 [24] | BMAC (n = 42 Patients) v hUCB-MSC (n = 32 Patients) Pain Subscale: 30.8 ± 11.0 v 31.6 ± 10.4 Function Subscale: 62.3 ± 11.9 v 63.1 ± 11.2 | BMAC (n = 42 Patients) v hUCB-MSC (n = 32 Patients) At latest follow-up Pain Subscale: 40.6 ± 9.1 v 42.8 ± 7.9 Function Subscale: 80.1 ± 15.0 v 82.4 ± 15.5 | Not Reported | Not Reported | Not Reported | Not Reported | Not Reported | Not Reported | BMAC (n = 42 Patients) v hUCB-MSC (n = 32 Patients) 52.9 ± 12.9 v 56.1 ± 10.6 | BMAC (n = 42 Patients) v hUCB-MSC (n = 32 Patients) At latest follow-up 79.2 ± 11.5 v 84.6 ± 15.5 | Not Reported | Not Reported |
D’Elia et al, Revista Brasileira de Ortopedia 2015 [19] | Not Reported | Not Reported | Not Reported | Not Reported | Not Reported | Not Reported | Not Reported | Not Reported | Not Reported | Not Reported | Not Reported | Control (n = 14) v PRP-BMAC (n = 11) 24 h post-op: 5.1 ± 2.9 v 4.4 ± 2.7 |