Table 2 Diagnostic Accuracy of Included Tests

Berthoud

Lactate/Glucose Ratio > 5

52.0%

98.10%

27

0.49

Synovial Lactate >/=10

40.0%

99.00%

41.6

0.61

Synovial Glucose < 1.0

32.0%

99.00%

33.3

0.69

Sigmund

SF mPCR

38.0%

100.00%

100

53.6

0

0.62

Sf Culture

29.0%

100.00%

100

50

0

0.71

Combined culture + mPCR

43.0%

100.00%

100

55.6

0

0.57

Tissue Culture

40.0%

100.00%

0

0.6

Chouk

PCT > 0.5 ng/ml

65.0%

91.00%

65

91

7.20

0.40

PCT > 0.2 ng/ml

80.0%

74.40%

44.4

93.5

3.10

0.30

Shu

Synovial Lactate >/=10

27.0%

97.00%

7.90

0.80

Synovial Lactate >/= 5

55.0%

76.00%

2.30

0.60

WBC >/= 50,000

27.0%

97.00%

7.90

0.80

WBC >/=100,000

18.0%

100.00%

10.00

0.80

Baillet

Calprotectin > 150 mg/L

73.0%

94.00%

84

88

11.64

0.29

Calprotectin < 52 mg/L

96.0%

44.00%

47

95

1.71

0.09

Morgenstern

Serum CRP > 10

78.0%

40.00%

48

71

1.30

0.55

Serum WBC > 10

62.0%

74.00%

65

71

2.38

0.51

SF Leuks > 50,000 or PMNs > 90%

94.0%

100.00%

100

97

0.00

0.06

Culture

46.0%

100.00%

100

74

0.00

0.54

PCR

23.0%

91.00%

63

65

2.56

0.77

Microcalorimetry

46.0%

94.00%

83

73

7.67

0.57

Pavic

Features of Sepsis (RR > 25 bpm, HR > 120 bpm, SBP < 100, temp > 38.5 w/I 24 h of review)

75.0%

72.10%

24.7

93.5

1.93

0.41

Ferreyra

Neutrophil count > 50,000

50.0%

94.40%

8.93

0.53

Neutrophil count < 15,000

92.3%

77.00%

4.013

0.10

Leukocyte count > 50,000

53.6%

91.70%

5.76

0.51

Leukocyte count > 70,000

39.3%

95.60%

8.93

0.63

Leukocyte count< 20,000

92.3%

70.60%

3.14

0.11

%Neutrophils> 90

71.4%

79.70%

3.52

0.36

%Neutrophils> 95

50.0%

89.00%

4.55

0.56

%Neutrophils< 80

96.2%

56.00%

2.19

0.07

%Neutrophils> 90 + no crystals

67.9%

92.80%

8.28

0.35

%Neutrophils> 95 + no crystals

50.0%

95.60%

11.36

0.52

> 50,000 leukocytes + no crystals

53.6%

95.10%

10.94

0.49

> 50,000 neutrophils + no crystals

35.7%

96.70%

10.82

0.66

Borzio

Synovial fluid WBC > 64,000

40.0%

90.00%

4

0.25

Kocher criteria + synovial WBC > 64,000

0.0%

98.60%

0

90.8

0

1.01419878

Paosong

Procalcitonin >/= 0.66

59.0%

86.00%

69.9

79.6

4.21

0.48

Lenski1

Synovial tot prot 4.3

55.6%

75.00%

2.22

0.59

Syn Gluc 40

56.6%

83.00%

3.33

0.52

Synovial Lactate 6.2

74.5%

87.20%

5.81

0.29

Syn WBC 14.4

71.2%

84.90%

4.71

0.34

Synovial IL6 7000

92.5%

64.10%

2.58

0.12

Omar

LE ++ or +++

94.7%

73.20%

34.6

98.9

3.54

0.08

LE ++ or +++ and GLC -

89.5%

99.20%

94.4

98.4

111.88

0.11

Baren

WBC > 50,000

72.7%

92.30%

9.09

0.30

% PMNs> 90

81.8%

67.30%

2.50

0.27

%PMNs> 85

88.6%

57.70%

2.05

0.23

%PMNs> 80

93.2%

53.80%

2.32

0.11

Lenski2

Synovial lactate >/= 4.3

89.5%

77.30%

3.94

0.14

Synovial Glucose< 51.5

65.9%

92.00%

8.24

0.37

(Gout) (synovial uric acid of 7.0)

78.1%

82.80%

4.53

0.27

(Gout) (Serum uric acid of 7.2)

70.00%

85.20%

4.73

0.35

Synovial LDH>/=1900

68.9%

88.90%

6.2

0.35

Synovial WBC>/=38.0

58.2%

86.20%

4.22

0.49

Synovial total prot of>/=4.4

48.90%

75.00%

1.96

0.68

Synovial IL-6 of>/=7000

93.90%

13.60%

1.09

0.44

Serum CRP of>/=0.5

92.30%

3.50%

0.96

2.23

Peripheral WBC>/=10.0

55.80%

41.40%

0.95

1.07

Talebi-Taher

WBC > 50,000

100%

66%

59.52

100

2.94

0.00

PMN > 75%

100.00%

94.00%

89.29

100

16.67

0.00

CRP > 18 mg/L

92.00%

30%

76.47

79.31

1.31

0.27

ESR (> 17 for men, > 25 for women)

100.00%

26.00%

40.32

100

1.35

0.00

TNF-alpha > 10

96.00%

62%

55.81

96.88

2.58

0.06

IL6 > 20

12.00%

92%

42.86

67.65

1.50

0.96

Serum PCT > 0.5 ng/ml

68.00%

80.00%

62.96

83.33

3.40

0.40

Synovial fluid PCT > 0.5%ng/ml

24.00%

96%

75

71.64

6.00

0.79