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Table 2 Diagnostic Accuracy of Included Tests

From: A narrative review of the last decade’s literature on the diagnostic accuracy of septic arthritis of the native joint

  Test Sensitivity Specificity NPV PPV LR+ LR-
Berthoud Lactate/Glucose Ratio > 5 52.0% 98.10%    27 0.49
Synovial Lactate >/=10 40.0% 99.00%    41.6 0.61
Synovial Glucose < 1.0 32.0% 99.00%    33.3 0.69
Sigmund SF mPCR 38.0% 100.00% 100 53.6 0 0.62
Sf Culture 29.0% 100.00% 100 50 0 0.71
Combined culture + mPCR 43.0% 100.00% 100 55.6 0 0.57
Tissue Culture 40.0% 100.00%    0 0.6
Chouk PCT > 0.5 ng/ml 65.0% 91.00% 65 91 7.20 0.40
PCT > 0.2 ng/ml 80.0% 74.40% 44.4 93.5 3.10 0.30
Shu Synovial Lactate >/=10 27.0% 97.00%    7.90 0.80
Synovial Lactate >/= 5 55.0% 76.00%    2.30 0.60
WBC >/= 50,000 27.0% 97.00%    7.90 0.80
WBC >/=100,000 18.0% 100.00%    10.00 0.80
Baillet Calprotectin > 150 mg/L 73.0% 94.00% 84 88 11.64 0.29
Calprotectin < 52 mg/L 96.0% 44.00% 47 95 1.71 0.09
Morgenstern Serum CRP > 10 78.0% 40.00% 48 71 1.30 0.55
Serum WBC > 10 62.0% 74.00% 65 71 2.38 0.51
SF Leuks > 50,000 or PMNs > 90% 94.0% 100.00% 100 97 0.00 0.06
Culture 46.0% 100.00% 100 74 0.00 0.54
PCR 23.0% 91.00% 63 65 2.56 0.77
Microcalorimetry 46.0% 94.00% 83 73 7.67 0.57
Pavic Features of Sepsis (RR > 25 bpm, HR > 120 bpm, SBP < 100, temp > 38.5 w/I 24 h of review) 75.0% 72.10% 24.7 93.5 1.93 0.41
Ferreyra Neutrophil count > 50,000 50.0% 94.40%    8.93 0.53
Neutrophil count < 15,000 92.3% 77.00%    4.013 0.10
Leukocyte count > 50,000 53.6% 91.70%    5.76 0.51
Leukocyte count > 70,000 39.3% 95.60%    8.93 0.63
Leukocyte count< 20,000 92.3% 70.60%    3.14 0.11
%Neutrophils> 90 71.4% 79.70%    3.52 0.36
%Neutrophils> 95 50.0% 89.00%    4.55 0.56
%Neutrophils< 80 96.2% 56.00%    2.19 0.07
%Neutrophils> 90 + no crystals 67.9% 92.80%    8.28 0.35
%Neutrophils> 95 + no crystals 50.0% 95.60%    11.36 0.52
> 50,000 leukocytes + no crystals 53.6% 95.10%    10.94 0.49
> 50,000 neutrophils + no crystals 35.7% 96.70%    10.82 0.66
Borzio Synovial fluid WBC > 64,000 40.0% 90.00%    4 0.25
Kocher criteria + synovial WBC > 64,000 0.0% 98.60% 0 90.8 0 1.01419878
Paosong Procalcitonin >/= 0.66 59.0% 86.00% 69.9 79.6 4.21 0.48
Lenski1 Synovial tot prot 4.3 55.6% 75.00%    2.22 0.59
Syn Gluc 40 56.6% 83.00%    3.33 0.52
Synovial Lactate 6.2 74.5% 87.20%    5.81 0.29
Syn WBC 14.4 71.2% 84.90%    4.71 0.34
Synovial IL6 7000 92.5% 64.10%    2.58 0.12
Omar LE ++ or +++ 94.7% 73.20% 34.6 98.9 3.54 0.08
LE ++ or +++ and GLC - 89.5% 99.20% 94.4 98.4 111.88 0.11
Baren WBC > 50,000 72.7% 92.30%    9.09 0.30
% PMNs> 90 81.8% 67.30%    2.50 0.27
%PMNs> 85 88.6% 57.70%    2.05 0.23
%PMNs> 80 93.2% 53.80%    2.32 0.11
Lenski2 Synovial lactate >/= 4.3 89.5% 77.30%    3.94 0.14
Synovial Glucose< 51.5 65.9% 92.00%    8.24 0.37
(Gout) (synovial uric acid of 7.0) 78.1% 82.80%    4.53 0.27
(Gout) (Serum uric acid of 7.2) 70.00% 85.20%    4.73 0.35
Synovial LDH>/=1900 68.9% 88.90%    6.2 0.35
Synovial WBC>/=38.0 58.2% 86.20%    4.22 0.49
Synovial total prot of>/=4.4 48.90% 75.00%    1.96 0.68
Synovial IL-6 of>/=7000 93.90% 13.60%    1.09 0.44
Serum CRP of>/=0.5 92.30% 3.50%    0.96 2.23
Peripheral WBC>/=10.0 55.80% 41.40%    0.95 1.07
Talebi-Taher WBC > 50,000 100% 66% 59.52 100 2.94 0.00
PMN > 75% 100.00% 94.00% 89.29 100 16.67 0.00
CRP > 18 mg/L 92.00% 30% 76.47 79.31 1.31 0.27
ESR (> 17 for men, > 25 for women) 100.00% 26.00% 40.32 100 1.35 0.00
TNF-alpha > 10 96.00% 62% 55.81 96.88 2.58 0.06
IL6 > 20 12.00% 92% 42.86 67.65 1.50 0.96
Serum PCT > 0.5 ng/ml 68.00% 80.00% 62.96 83.33 3.40 0.40
Synovial fluid PCT > 0.5%ng/ml 24.00% 96% 75 71.64 6.00 0.79
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