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Table 3 Comparison of preoperative and postoperative clinical outcomes according to the presence of radiological worsening in both groups

From: Comparative matched-pair cohort analysis of the short-term clinical outcomes of mesenchymal stem cells versus hyaluronic acid treatments through intra-articular injections for knee osteoarthritis

  MSC HA
Radiological worsening Radiological worsening
Presence (n = 2) Absence (n = 28) P valuea Presence (n = 6) Absence (n = 24) P valuea
VAS
 Baseline 8.0 ± 1.4 8.4 ± 1.1 0.604 8.5 ± 1.0 8.0 ± 1.1 0.359
 1 year 5.5 ± 2.1 4.8 ± 1.1 0.372 5.7 ± 1.0 5.3 ± 1.0 0.404
P valueb <  0.001 <  0.001   <  0.001 <  0.001  
IKDC score
 Baseline 42.0 ± 11.3 36.7 ± 7.7 0.366 35.5 ± 4.6 40.1 ± 6.4 0.110
 1 year 68.0 ± 8.5 65.9 ± 5.1 0.588 60.3 ± 6.1 62.5 ± 7.2 0.512
P valueb <  0.001 <  0.001   <  0.001 <  0.001  
Lysholm score
 Baseline 57.5 ± 10.6 54.2 ± 6.2 0.489 51.7 ± 4.2 56.0 ± 7.8 0.095
 1 year 78.0 ± 11.3 77.6 ± 6.1 0.927 70.8 ± 5.8 74.6 ± 5.7 0.160
P valueb <  0.001 <  0.001   <  0.001 <  0.001  
  1. Data are expressed as mean ± standard deviation. MSC Mesenchymal stem cell, HA Hyaluronic acid, VAS Visual analog scale, IKDC International Knee Documentation Committee
  2. aMann–Whitney U test
  3. bWilcoxon signed-rank test for comparison of clinical outcomes at baseline versus I year after the injection