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Journal of Experimental Orthopaedics

Table 1 Summary of Knee Morphometry Parameters

From: Viscosupplementation may preserve tibial cartilage and collagen in osteoarthritis: findings from a preclinical model of osteoarthritis

 

Single Injection1

Three Injections1

Vehicle (PBS) Control

IA-BioHA

Hylan G-F 20

Vehicle (PBS) Control

IA-BioHA

Mean (SE)

  

% Change2

 

% Change2

  

% Change2

Total tibial cartilage degeneration width (μm)

1926.7 (17.9)2

1797.8 (54.0)

−7.6

1853.3 (50.3)

−4.3

1897.8 (22.4)

1780. 0 (59.2)

−7.0

Substantial tibial cartilage degeneration width (μm)

653.3 (69.3)

624.4 (63.3)

−4.4

693.3 (65.1)

6.1

620.0 (69.9)

573.3 (52.5)

−7.5

Total cartilage degeneration score, 3-zone sum

6.0 (0.5)

5.73 (0.4)

−5.1

6.3 (0.5)

4.4

6.2 (0.5)

5.3 (0.4)

−15.4

Total cartilage degeneration depth ratio, mean (μm)

0.33 (0.03)

0.32 (0.03)

−2.6

0.35 (0.03)

4.6

0.34 (0.03)

0.29 (0.03)

−14.6

Femoral cartilage degeneration score

2.3 (0.35)

1.8 (0.24)

−20.2

2.8 (0.33)

24.1

1.8 (0.28)

1.3 (0.25)

−24.4

Collagen width – total (μm)

0.35 (0.02)

0.36 (0.03)

−5.6

0.34 (0.02)

0.5

0.37 (0.02)

0.29 (0.02)

−20.7

  1. Abbreviations: IA-BioHA Intra-articular biologically derived hyaluronic acid, PBS Phosphate buffered saline
  2. 1N = 15 animals/group. Results represent the mean (SE)
  3. 2Analysis of the percent change relative to vehicle control across all histopathology parameters demonstrated a statistically significant difference in the number of improved responses after a single (p < 0.0001) or three (p < 0.0001) weekly injections of IA-BioHA; the difference between vehicle control and a single injection of hylan G-F 20 was not significant
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