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Table 1 Summary of Knee Morphometry Parameters

From: Viscosupplementation may preserve tibial cartilage and collagen in osteoarthritis: findings from a preclinical model of osteoarthritis

 Single Injection1Three Injections1
Vehicle (PBS) ControlIA-BioHAHylan G-F 20Vehicle (PBS) ControlIA-BioHA
Mean (SE)  % Change2 % Change2  % Change2
Total tibial cartilage degeneration width (μm)1926.7 (17.9)21797.8 (54.0)−7.61853.3 (50.3)−4.31897.8 (22.4)1780. 0 (59.2)−7.0
Substantial tibial cartilage degeneration width (μm)653.3 (69.3)624.4 (63.3)−4.4693.3 (65.1)6.1620.0 (69.9)573.3 (52.5)−7.5
Total cartilage degeneration score, 3-zone sum6.0 (0.5)5.73 (0.4)−5.16.3 (0.5)4.46.2 (0.5)5.3 (0.4)−15.4
Total cartilage degeneration depth ratio, mean (μm)0.33 (0.03)0.32 (0.03)−2.60.35 (0.03)4.60.34 (0.03)0.29 (0.03)−14.6
Femoral cartilage degeneration score2.3 (0.35)1.8 (0.24)−20.22.8 (0.33)24.11.8 (0.28)1.3 (0.25)−24.4
Collagen width – total (μm)0.35 (0.02)0.36 (0.03)−5.60.34 (0.02)0.50.37 (0.02)0.29 (0.02)−20.7
  1. Abbreviations: IA-BioHA Intra-articular biologically derived hyaluronic acid, PBS Phosphate buffered saline
  2. 1N = 15 animals/group. Results represent the mean (SE)
  3. 2Analysis of the percent change relative to vehicle control across all histopathology parameters demonstrated a statistically significant difference in the number of improved responses after a single (p < 0.0001) or three (p < 0.0001) weekly injections of IA-BioHA; the difference between vehicle control and a single injection of hylan G-F 20 was not significant