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Fig. 5 | Journal of Experimental Orthopaedics

Fig. 5

From: Viscosupplementation may preserve tibial cartilage and collagen in osteoarthritis: findings from a preclinical model of osteoarthritis

Fig. 5

TNFα staining on the medial tibial surface. a Uninjected left knee. b PBS injected in the right knee. c IA-BioHA (0.5 mg/rat) injected at Days 7, 14, and 21 in the right knee. The large arrow identifies a cartilage lesion. There are numerous TNFα-positive cells in the bone marrow (arrowhead) and minimal multifocal-positive cells in the synovium (small arrow). The disease process and IA-BioHA treatment did not result in a significant increase in TNFα immunostaining. F – femur; M – meniscus; OP – osteophyte; T – tibia. Images were acquired at 50x magnification

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