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Fig. 4 | Journal of Experimental Orthopaedics

Fig. 4

From: Enhancement of chondrogenic differentiation supplemented by a novel small compound for chondrocyte-based tissue engineering

Fig. 4

The effects of combination of TD198946 and BMP-2 on engineered cartilage generation. a Histological images for Safranin-O, IHC for type I and II collagen (Low and high magnification views) of engineered cartilage at day 14. Upper three row panels: treated with 50 ng/mL BMP-2. Lower panels: treated with 100 ng/mL BMP-2. Left panels: treated with vehicle. Right panels: treated with 10 nM TD198946. Scale bars = 2 mm (Low magnification: upper panels) and 100 μm (High magnification: below Low magnification). Upper high magnification views are of central zone and lower high magnification views are of surface zone of engineered cartilage. High magnification panels are magnified images of the specific zone represented by the square on the low magnification view. b Histological images for Safranin-O, IHC for type I and II collagen of engineered cartilage at day 28. Scale bar and panels are displayed in the same manner as a. Abbreviations: IHC, Immunohistochemistry

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