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Journal of Experimental Orthopaedics

Table 5 The bone turnover markers levels at 6 and 12 months in the naïve and switch groups

From: Effects of denosumab on bone mineral density and bone turnover markers in rheumatoid arthritis patients switching from bisphosphonates

 

6 months

12 months

Naïve group (n = 25)

Switch group (n = 11)

P

Naïve group (n = 25)

Switch group (n = 11)

P

Total-PINP (ng/ml)

30.6 ± 3.6

25.6 ± 3.8

n.s

32.5 ± 3.5

29.9 ± 5.7

n.s

TRACP-5b (mU/dl)

244.8 ± 27.6

278.4 ± 47.9

n.s

250.2 ± 22.4

276.6 ± 40.0

n.s

ucOC (ng/ml)

1.6 ± 0.2

1.1 ± 0.3

n.s

1.5 ± 0.2

1.4 ± 0.4

n.s

  1. Data are presented as means ± standard deviation (SD), Naïve group: treatment-naïve group; Switch group: transitioning from bisphosphonate group; total-PINP: total-procollagen type I N-terminal propeptide; TRACP-5b: tartrate-resistant acid phosphatase-5b; ucOC: undercarboxylated osteocalcin. P values from Mann-Whitney U tests, for the bone turnover markers in the naïve group versus the switch group
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