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Table 5 The bone turnover markers levels at 6 and 12 months in the naïve and switch groups

From: Effects of denosumab on bone mineral density and bone turnover markers in rheumatoid arthritis patients switching from bisphosphonates

  6 months 12 months
Naïve group (n = 25) Switch group (n = 11) P Naïve group (n = 25) Switch group (n = 11) P
Total-PINP (ng/ml) 30.6 ± 3.6 25.6 ± 3.8 n.s 32.5 ± 3.5 29.9 ± 5.7 n.s
TRACP-5b (mU/dl) 244.8 ± 27.6 278.4 ± 47.9 n.s 250.2 ± 22.4 276.6 ± 40.0 n.s
ucOC (ng/ml) 1.6 ± 0.2 1.1 ± 0.3 n.s 1.5 ± 0.2 1.4 ± 0.4 n.s
  1. Data are presented as means ± standard deviation (SD), Naïve group: treatment-naïve group; Switch group: transitioning from bisphosphonate group; total-PINP: total-procollagen type I N-terminal propeptide; TRACP-5b: tartrate-resistant acid phosphatase-5b; ucOC: undercarboxylated osteocalcin. P values from Mann-Whitney U tests, for the bone turnover markers in the naïve group versus the switch group