Growth factor levels in leukocyte-poor platelet-rich plasma and correlations with donor age, gender, and platelets in the Japanese population

Journal of Experimental Orthopaedics

Table 2 Statistics including correlation with age for 10 analytes

Variable	20’s N = 13	30’s N = 13	40’s N = 13	P by Kruskal-Wallis test	P value for pairwise comparison*			Spearman’s correlation with age	P
Variable	20’s N = 13	30’s N = 13	40’s N = 13	P by Kruskal-Wallis test	20’s vs 30 ‘s	20’s vs 40 ‘s	30’s vs 40 ‘s	Spearman’s correlation with age	P
PDGF-BB (ng/mL)	3.3 [2.4, 6.5]	3.5 [1.4, 6.2]	2.1 [1.4, 4.9]	0.030	0.72	0.013	0.094	−0.32	0.049
TGF-β1 (ng/mL)	15.4 [11.0, 24.7]	17.1 [11.4, 31.9]	13.1 [11.2, 21.1]	0.12	–	–	–	−0.17	0.295
VEGF (pg/mL)	104 [21, 534]	290 [65, 591]	196 [41, 725]	0.20	–	–	–	0.19	0.325
EGF (pg/mL)	722 [489, 923]	861 [489, 1736]	612 [226, 938]	0.029	0.10	0.18	0.026	−0.19	0.255
FGF (pg/mL)	11 [5, 15]	12 [4, 40]	10 [4, 19]	0.33	–	–	–	−0.20	0.211
HGF (pg/mL)	431 [285, 596]	492 [357, 733]	451 [338, 560]	0.11	–	–	–	0.16	0.341
IGF-1 (ng/mL)	90 [58, 139]	70 [60, 96]	63 [47, 104]	0.027	0.18	0.024	0.10	−0.39	0.014
PLT (×10⁴/μL)	23 [16, 26]	26 [20, 34]	21 [18, 32]	0.004	0.003	0.94	0.024	0.03	0.87
PLT (PRP) (×10⁴/μL)	39 [28, 56]	47 [32, 82]	34 [23, 49]	0.004	0.077	0.16	0.001	−0.23	0.151

Values in the table are shown as median [minimum, maximum]
PDGF-BB platelet-derived growth factor-BB, TGF-β1 transforming growth factors-β1, VEGF vascular endothelial growth factor, EGF epidermal growth factor, FGF fibroblast growth factor, HGF hepatocyte growth factor, IGF-1 insulin-like growth factor-1
*Fisher’s LSD for multiplicity adjustment