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Fig. 1 | Journal of Experimental Orthopaedics

Fig. 1

From: What role does metal allergy sensitization play in total knee arthroplasty revision?

Fig. 1

(a) Chronic inflammatory nidus in a nickel-sensitive synovium after total knee arthroplasty (H&E × 40). Immunohistochemical staining for CD4+ T-cell (b) and CD8+ T cell (c) markers shows a relative predominance of CD4+ infiltrate, consistent with a delayed-type hypersensitivity (CD4+ immunohistochemistry X 40). (d) Synovial sample from a patient in the control group (H&E × 40). Immunohistochemical staining for CD4+ T cell (e) and CD8+ T cell (f) markers shows similar levels of inflammatory infiltrate (CD8+ immunohistochemistry × 40). Black arrowhead denotes CD4+ staining cells

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