Current trends in tendinopathy: consensus of the ESSKA basic science committee. Part II: treatment options

Journal of Experimental Orthopaedics

Table 2 Gene therapy applications for tendinopathies

Systems	Genes	Applications	References
Non-viral vectors	Tnmd	tenogenesis in vitro and in vivo	Jiang et al. 2016
	PDGF-B	tendon repair in vitro and in vivo	Nakamura et al. 1998, Wang et al. 2004
	VEGF	tendon repair in vitro	Wang et al., 2005
	PRDX5	tenogenesis in vitro	Yuan et al. 2004
	CXCL13	tendon-bone healing in vivo	Tian et al. 2015
	SCX	tenogenesis in vitro, tendon repair in vivo	Chen et al. 2014
AdV vectors	FGF-2	tenogenesis in vitro	Cai et al. 2013
	GDF-5	tendon repair in vivo	Rickert et al. 2005
	IGF-I	tendon repair in vivo	Schnabel et al. 2009
	TGF-β	tendon repair in vivo	Majewski et al. 2012
	BMP-12	tenogenesis in vitro, tendon repair in vivo	Lou et al. 2001, Majewski et al. 2008
	MKX	tenogenesis in vitro, tendon repair in vivo	Otabe et al. 2015
RV/LV vectors	Periostin	tenogenesis in vitro, tendon repair in vivo	Noack et al. 2014
	shRNA TOB1	tendon-bone healing in vivo	Gao et al. 2016
	miR-135a ROCK1	tenogenesis in vitro	Chen et al. 2015
rAAV vectors	VEGF	tendon repair in vivo	Tang et al. 2016
	FGF-2	tenogenesis in vitro, tendon repair in vivo	Tang et al. 2008, 2014, 2016, Wang et al., 2005, 2007
	GDF-5	tendon reconstruction in vivo	Basile et al. 2008, Hasslund et al. 2014

AdV adenoviruses, RV retroviruses, LV lentiviruses, rAAV recombinant adeno-associated virus vectors, Tnmd tenomodulin, PDGF-B platelet-derived growth factor B, VEGF vascular endothelial growth factor, PRDX5 peroxiredoxin, CXCL13 CXC chemokine ligand 13, SCX scleraxis, FGF-2 basic fibroblast growth factor, GDF-5 growth and differentiation factor 5, IGF-I insulin-like growth factor I, TGF-β transforming growth factor beta, BMP-12 bone morphogenetic protein 12, MKX Mohawk, shRNA TOB1 short hairpin RNA against the transducer of ERB2,1, miR-135a ROCK1 microRNA against Rho-associated coiled-coil protein kinase 1