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Table 2 Gene therapy applications for tendinopathies

From: Current trends in tendinopathy: consensus of the ESSKA basic science committee. Part II: treatment options

Systems Genes Applications References
Non-viral vectors Tnmd tenogenesis in vitro and in vivo Jiang et al. 2016
PDGF-B tendon repair in vitro and in vivo Nakamura et al. 1998, Wang et al. 2004
VEGF tendon repair in vitro Wang et al., 2005
PRDX5 tenogenesis in vitro Yuan et al. 2004
CXCL13 tendon-bone healing in vivo Tian et al. 2015
SCX tenogenesis in vitro, tendon repair in vivo Chen et al. 2014
AdV vectors FGF-2 tenogenesis in vitro Cai et al. 2013
GDF-5 tendon repair in vivo Rickert et al. 2005
IGF-I tendon repair in vivo Schnabel et al. 2009
TGF-β tendon repair in vivo Majewski et al. 2012
BMP-12 tenogenesis in vitro, tendon repair in vivo Lou et al. 2001, Majewski et al. 2008
MKX tenogenesis in vitro, tendon repair in vivo Otabe et al. 2015
RV/LV vectors Periostin tenogenesis in vitro, tendon repair in vivo Noack et al. 2014
shRNA TOB1 tendon-bone healing in vivo Gao et al. 2016
miR-135a ROCK1 tenogenesis in vitro Chen et al. 2015
rAAV vectors VEGF tendon repair in vivo Tang et al. 2016
FGF-2 tenogenesis in vitro, tendon repair in vivo Tang et al. 2008, 2014, 2016, Wang et al., 2005, 2007
GDF-5 tendon reconstruction in vivo Basile et al. 2008, Hasslund et al. 2014
  1. AdV adenoviruses, RV retroviruses, LV lentiviruses, rAAV recombinant adeno-associated virus vectors, Tnmd tenomodulin, PDGF-B platelet-derived growth factor B, VEGF vascular endothelial growth factor, PRDX5 peroxiredoxin, CXCL13 CXC chemokine ligand 13, SCX scleraxis, FGF-2 basic fibroblast growth factor, GDF-5 growth and differentiation factor 5, IGF-I insulin-like growth factor I, TGF-β transforming growth factor beta, BMP-12 bone morphogenetic protein 12, MKX Mohawk, shRNA TOB1 short hairpin RNA against the transducer of ERB2,1, miR-135a ROCK1 microRNA against Rho-associated coiled-coil protein kinase 1