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Table 1 Demographics and clinical data of the two study groups

From: Sublingual sufentanil tablet system Zalviso® for postoperative analgesia after knee replacement in fast track surgery: a pilot observational study

Characteristic SSTS cFNB p value
(95) (87)
Patient age (years) 66.2 ± 7.6 68.7 ± 6.6 < 0.05a
Female/Male 66/29 46/41 < 0.001
BMI (mean ± SD) 29.3 ± 5.0 29.8 ± 5.4 nsa
Comorbidities, n (%)
 Hypertension 63 (66.3) 36 (41.4) < 0.001a
 Diabetes 12 (12.6) 14 (16.1) nsb
 Heart diseases 13 (13.7) 12 (13.8) nsb
 Other 57 (60.0) 6 (6.9) < 0.001b
Pain, mean ± SD
 NRS T1 1.96 ± 0.93 0.60 ± 1.06 < 0.001b
 NSR T2 1.79 ± 0.90 0.40 ± 0.58 < 0.001b
 NSR T3 1.21 ± 0.94 0.18 ± 0.42 < 0.001b
 NRS T4 x 0.16 ± 0.41  
 mNRS T1 1.85 ± 0.96 2.06 ± 1.9 < 0.001b
 mNRS T2 1.62 ± 1.15 1.94 ± 1.5 < 0.01b
 mNRS T3 1.16 ± 0.73 1.33 ± 0.93 < 0.05b
 mNRS T4 x 1.94 ± 1.08  
Rescue analgesic, n (%)
 T1 5 (5.3) 22 (25.3) < 0.001c
 T2 0 (0.0) 13 (14.9)  
 T3 0 (0.0) 9 (10.3)  
AEs, n (%)
 Overall n. events 7 132 < 0.001c
 Overall n. patients (%) Nausea 1 (1) 42 (48) < 0.001c
 Vomiting 2 (1) 24 (28) < 0.001c
 PONV 2 (2) 61 (70) < 0.0013
 Erythema 1 (1) 5 (6) ns
 Dizziness 1 (1) 15 (17) < 0.001c
 Numbness 0 47 (54)  
LOS, n patients (%)
  = 4 days 95 (100.0%) 32 (36.8%)  
 5–7 days 0 (0.0%) 55 (63.2%)  
  1. Abbreviations: AEs adverse events, BMI body mass index, LOS length of hospital stay, NRS numeric rating score pain at rest, mNRS movement-evoked NRS. T1-T4, postoperative days 1–4
  2. Statistical analyses used: aT-Test; b Kruskal-Wallis; c Chi-squared test