From: Scaffold-free tissue engineering for injured joint surface restoration
Authors | Journal | Year | Experimental Model | Scaffold-free Technique | Shape | Cell Source | Matrix | Amount of Cells | Defect Size (in vivo) | Graft fixation (in vivo) |
---|---|---|---|---|---|---|---|---|---|---|
Adkisson HD | Clin Orthop Relat Res | 2001 | in vitro | High-density in Monolayer | Disc | Chondrocyte | Catilage-like | 2 × 105/cm2 per plate | N/A | N/A |
Mainil-Varlet P, et al. | Osteoarthritis Cartilage | 2001 | Minipig | Bioreactor | Spheroid | Chondrocyte | Catilage-like | 2 × 107 | 4 mm diameter(Full-thickness cartilage defect) | Press-fit |
Anderer U, et al. | J Bone Miner Res | 2002 | in vitro | Self Aggregating | Spheroid | Chondrocyte | Catilage-like | 2 × 105 | N/A | N/A |
Masuda K, et al. | J Orthop Res | 2003 | in vitro | Alginate Recovered Chondrocyte Method | Sheet | Chondrocyte | Catilage-like | 4 × 106per mL | N/A | N/A |
Lu Y, et al. | J Knee Surg | 2005 | Sheep | High-density in Monolayer | Disc | Chondrocyte | Catilage-like | 2 × 105/cm2 per plate | 5.5 mm diameter 400–500 μm depth | Suture |
Stoddart MJ, et al. | J Cell Mol Med | 2006 | in vitro | Cell Pellet After Culture in Alginate | Disc | Chondrocyte | Catilage-like | 4 × 106per mL | N/A | N/A |
Stoddart MJ, et al. | Biotechnol Bioeng | 2006 | in vitro | Cell Pellet After Culture in Alginate | Spheroid | Chondrocyte | Catilage-like | 4 × 106per mL | N/A | N/A |
Kaneshiro N, et al. | Biochem Biophys Res Commun | 2006 | in vitro | Layered Chondrocyte Sheet | Sheet | Chondrocyte | Catilage-like | 1 × 104per cm2 | N/A | N/A |
Hu JC, et al. | Tissue Eng | 2006 | in vitro | High-density in Monolayer | Disc | Chondrocyte | Catilage-like | 5.5 × 106 | N/A | N/A |
Park K, et al. | Artificial Organs | 2006 | Pig | High-density in Monolayer | Disc | Chondrocyte | Catilage-like | 1.9 × 105/cm2per plate | 6 mm diameter 3–4 mm depth | Bovine collagen gel |
Brehm W, et al. | Osteoarthritis Cartilage | 2006 | Goat | Bioreactor | Disc | Chondrocyte | Catilage-like | 2 × 107 | 6 mm diameter 0.8 mm depth | Periosteal falp, PRP, Fibrin |
Hayes AJ, et al. | J Histochem Cytochem | 2007 | in vitro | High-density in Monolayer | Sheet | Chondrocyte | Catilage-like | 6 × 106 | N/A | N/A |
aAndo W, et al. | Biomaterials | 2007 | Pig | High-density in Monolayer | Sheet | Synovial MSC | Collagen I, III-rich | 4 × 105/cm2per plate | 8.5 mm diameter2 mm depth | Nether glue nor suture |
Murdoch AD, et al. | Stem Cells | 2007 | in vitro | Transwell Culture | Disc | Bone Marrow MSC | Catilage-like | 5 × 105 | N/A | N/A |
aAndo W, et al. | Tissue Eng Part A | 2008 | in vitro | High-density in Monolayer | Sheet | Synovial MSC | Catilage-like | 4 × 105/cm2per plate | N/A | N/A |
Ofek G, et al. | ProS One | 2008 | in vitro | High-density in Monolayer | Spheroid | Chondrocyte | Catilage-like | 5.5 × 106 | N/A | N/A |
Nagai T, et al. | Tissue Eng Part A | 2008 | Rabbit | High-density in Monolayer | Disc | Chondrocyte | Catilage-like | 6 × 106 | 5 mm diameter3 mm depth | Nether glue nor suture |
Jubel A, et al. | Am J Sports Med | 2008 | Sheep | Cell Pellet After Culture in Alginate | Disc | Chondrocyte | Catilage-like | 4 × 106 per mL | 4 mm diameter(Full-thickness cartilage defect) | Periosteal flap |
Schubert T, et al. | Int J Mol Med | 2009 | Mouse | Self Aggregating | Spheroid | Chondrocyte | Catilage-like | 2 × 105 | 5 mm diameter3-4 mm depth(Human cartilageco-implant model) | Nether glue nor suture |
Lewis PB, et al. | J Knee Surg | 2009 | Goat | High-density in Monolayer | Disc | Chondrocyte | Catilage-like | 2 × 105/cm2per plate | 4 or 6 mm diameter | Fibrin glue |
aShimomura K, et al. | Biomaterials | 2010 | Pig | High-density in Monolayer | Sheet | Synovial MSC | Collagen I, III-rich | 4 × 105/cm2per plate | 8.5 mm diameter2 mm depth | Nether glue nor suture |
Kraft JJ, et al. | Cartilage | 2011 | in vitro | Self Aggregating | Disc | Chondrocyte | Catilage-like | 2 × 107per mL | N/A | N/A |
Zhang B, et al. | Tissue Eng Part C | 2011 | in vitro | Self Aggregating | Round or Oval | Bone MarrowMSC | Catilage-like | 2.5 × 107per mL | N/A | N/A |
Maeda S, et al. | J Biosci Bioeng | 2011 | in vitro | Culture on Membrane (polyethylene terephthalate) | Disc | Bone MarrowMSC | Catilage-like | 3.1 × 106 | N/A | N/A |
Cheuk YC, et al. | J Orthop Res | 2011 | Rabbit | Pellet Culture | Spheroid | AllogenicChondrocyte | Not assessed | 5 × 105 | 3 mm diameter3 mm depth | Press-fit |
Yoshioka T, et al. | J Tissue Eng Regen Med | 2011 | Rabbit | Rotatory Culture(Bioreactor) | Spheroid | Bone MarrowMSC | Mainly hyaline-like appearance | 1.5 - 3.0 × 107 | 5 mm diameter4 mm depth | Nether glue nor suture |
Qu C, et al. | Cell Tissue Res | 2012 | in vitro | Transwell Culture | Disc | Chondrocyte | Catilage-like | 6 × 106 | N/A | N/A |
aAndo W, et al. | Eur Cell Mater | 2012 | Pig | High-density in Monolayer | Sheet | Synovial MSC | Collagen I, III-rich | 4 × 105/cm2per plate | 8.5 mm diameter2 mm depth | Nether glue nor suture |
Ebihara G, et al. | Biomaterials | 2012 | Minipig | Layered Chondrocyte Sheet | Sheet | Chondrocyte | Catilage-like | 5 × 104per cm2 | 6 mm diameter5 mm depth | Suture |
Sato Y, et al. | J Biosci Bioeng | 2013 | in vitro | Culture on Membrane (polyethylene terephthalate) | Disc | Bone MarrowMSC | Catilage-like | 1.86 × 106 | N/A | N/A |
Brenner JM, et al. | Biotechnol Prog | 2013 | in vitro | Bioreactor | Sheet | Chondrocyte | Catilage-like | 2 × 104 | N/A | N/A |
Giardini-Rosa R, et al. | Tissue Eng Part A | 2014 | in vitro | Bioreactor | Sheet | Chondrocyte | Catilage-like | 6.5 or 13 × 103per cm2 | N/A | N/A |
Mohanraj B, et al. | J Biomech | 2014 | in vitro | High-density in Monolayer | Disc | Chondrocyte | Catilage-like | 1 × 106 | N/A | N/A |
Liu T, et al. | Tissue Eng Part A | 2014 | in vitro | Self Assembling | Disc | Fat Pad-derivedStem Cell | Catilage-like | 3.8 × 106 | N/A | N/A |
Ylärinne JH, et al. | Cell Tissue Res | 2014 | in vitro | Transwell Culture | Disc | Chondrocyte | Catilage-like | 6 × 106 | N/A | N/A |
Oda K, et al. | J Orthop Sci | 2014 | Rabbit | High-density in Monolayer | Disc | Chondrocyte | Catilage-like | 6 × 106per cm2 | 4 mm diameter(Osteochondral defect) | Not addressed |
Ishihara K, et al. | J Orthop Surg Res | 2014 | Rabbit | Spheroid Formation | Cylinder | Bone MarrowMSC | Not stained with Safranion O | 4 × 104per well | 4.8 mm diameter4-5 mm depth | Nether glue nor suture |
Brenner JM, et al. | Artificial Organs | 2014 | Rabbit | Bioreactor | Sheet | Chondrocyte | Catilage-like | 2 × 104 | 4 mm diameter(Chondral only defect) | Fibrin glueand Suture |
aFujie H, et al. | J Biomech | 2015 | Pig | High-density in Monolayer | Sheet | Synovial MSC | Collagen I, III-rich | 4 × 105/cm2per plate | 8.5 mm diameter2 mm depth | Nether glue nor suture |
Yamashita A, et al. | Stem Cell Reports | 2015 | Minipig | Staged Differentiation Media | Spheroid | iPSC | Catilage-like | 1-2 × 105 | Not addressed | Fibrin glue |
He P, et al. | Acta Biomater | 2016 | in vitro | Culture on Alginate-based Micro-cavity Hydrogel | Disc | iPSC | Catilage-like | 1 × 107per mL | N/A | N/A |
Islam A, et al. | Eur Cell Mater | 2016 | in vitro | Pellet Culture | Spheroid | Umbilical Cord MSC | Catilage-like | 5 × 104 | N/A | N/A |
aYasui Y, et al. | Tissue Eng Part A | 2016 | in vitro | High-density in Monolayer | Sheet | Synovial MSC | Catilage-like | 4 × 105/cm2per plate | N/A | N/A |
Kimura T, et al. | Tissue Eng Part A | 2016 | in vitro | Staged Differentiation Media | Spheroid | iPSC | Catilage-like | 1-2 × 105 | N/A | N/A |
Bartz C, et all. | J Transl Med | 2016 | ex vivo | Self Aggregating | Spheroid | Chondrocyte | Catilage-like | 2 × 105 | 4 mm diameter | Nether glue nor suture |
aKoizumi K, et al. | OsteoarthritisCartilage | 2016 | Rat | High-density in Monolayer | Sheet | Synovial MSC | Collagen I, III-rich | 4 × 105/cm2per plate | 1.5 mm diameter1 mm depth | Nether glue nor suture |
Itokazu M, et al. | Cartilage | 2016 | Rat | Culture on Membrane (polyethylene terephthalate) | Disc | Bone MarrowMSC | Catilage-like | 1.86 × 106 | 2 mm diameter1 mm depth | Fibrin glue |
Becher C, et al. | J Orthop Surg Res | 2017 | Clinical | Self Aggregating | Spheroid | Chondrocyte | Catilage-like | 2 × 105 | 4 - 10 cm2ICRS grade III or IV | Not addressed |