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Table 3 Biomarker Longitudinal Changes a

From: Differences in biomarkers of cartilage matrix turnover and their changes over 2 years in adolescent and adult volleyball athletes

  BL Open Adolescents P-value BL Closed Adolescents P-value Adults P-value
CILP-2 [ng/ml] 0.79 (−0.32, 1.9) 0.116 1.8 (−0.72, 4.4) 0.144 1.2 (0.23, 2.1) 0.021*
COMP [U/l] 1.3 (−1.4, 4.1) 0.917 0.13 (−8.5, 8.7) >0.999 0.44 (−1.4, 2.3) 0.948
sC2C [ng/ml] −54.3 (−131.4, 22.7) 0.116 −36.3 (−142.6, 70.1) 0.273 43.1 (−14.4, 100.7) 0.17
CPII [ng/ml] −128.8 (−231.4, −26.2) 0.028* −57.9 (−253.1, 137.2) 0.273 73.4 (−75.1, 221.8) 0.586
C2C-HUSA [ng/mmol] −7.8 (−17.8, 2.0) 0.012* −2.5 (−6.7, 1.6) 0.080 0.1079 (−0.0061, 0.22) 0.033*
CTX-II [ng/mmol] −11,051.3 (−18,920.3, −3182.2) 0.002* −2652.8 (−7578.2, 2272.7) 0.080 25.6 (−18.5, 69.9) 0.26
  1. *Statistically significant difference (P < 0.05)
  2. a BL baseline, BL Open Adolescents adolescents with open growth plates at BL, BL Closed Adolescents adolescents with closed growth plates at BL. Data provided as mean (95% confidence interval)