Table 2 Biomarker Values ^a

CILP-2 [ng/ml]

BL

0.56 (−0.059, 1.2)

0.98 (0.60, 1.4)

1.4 (0.90, 2.0)

0.13

FU

2.2 (1.4, 3.1)

3.0 (1.3, 4.6)

2.6 (2.0, 3.2)

0.775

COMP [U/l]

BL

15.2 (11.8, 18.5)

11.5 (3.7, 19.3)

12.8 (10.8, 14.8)

0.406

FU

15.0 (13.1, 16.8)

12.1 (6.7, 17.6)

13.4 (11.8, 15.0)

0.537

sC2C [ng/ml]

BL

167.9 (108.6, 227.1)

137.5 (18.6, 256.4)

120.5 (90.3, 150.7)

0.177

FU

123.3 (105.8, 140.7)

113.4 (70.2, 156.6)

159.6 (120.0, 199.3)

0.241

CPII [ng/ml]

BL

310.4 (212.8, 407.9)

177.2 (−5.1, 359.5)

199.3 (139.7, 258.9)

0.164

FU

176.9 (139.7, 214.1)

161.8 (42.5, 281.0)

262.9 (144.7, 381.0)

0.862

C2C-HUSA [ng/mmol]

BL

7.4 (2.3, 12.6)

3.6 (0.21, 7.0)

0.43 (0.33, 0.53)

<0.001 ^*

0.007 ^**

FU

3.2 (1.9, 4.5)

1.3 (0.53, 2.0)

0.54 (0.39, 0.69)

<0.001 ^*

0.112 ^**

CTX-II [ng/mmol]

BL

10,675.6 (6038.9, 15,312.3)

3710.8 (259.7, 7161.9)

255.4 (177.2, 333.7)

<0.001 ^*

0.030 ^**

FU

3312.2 (2255.6, 4368.9)

1499.8 (1181.6, 1818.1)

281.1 (203.5, 358.7)

<0.001 ^*

0.034 ^**