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Table 2 Outcome study reported data metrics

From: Bone marrow aspirate concentrate for the treatment of osteochondral lesions of the talus: a systematic review of outcomes

Study Study Size Treatment Additional Treatment Preoperative AOFAS Postoperative AOFAS Preoperative FAOS Postoperative FAOS Preoperative SF-12 Postoperative SF-12 Radiologic findings Second-look arthroscopy Complications
Hannon et al. 2016 N = 34 BMS alone Vs BMS with BMAC None    BMS 54.8 BMS + BMAC 60.6 BMS 68.3 BMS + BMAC 77.6 BMS 38.5 BMS + BMAC 42.5 BMS 55.3 BMS + BMAC 61.9 Total MOCART score BMS: 55.8 BMAC + BMS: 73.0 (BMAC with significantly greater defect filling, border repair integration, and surface tissue repair at 2 year follow-up) Not performed BMS: 1 subchondral cyst formation BMAC/BMS: 2 superficial peroneal nerve dysesthesias
Kennedy and Murawski 2011 N = 72 Osteochondral autograft soaked in BMAC with synthetic filler soaked in BMAC None    52.67 86.2 59.4 88.6 MRI: In 1 ankle, small cyst formation beneath graft site at 28 months Not performed 3 donor site knee pain, 1 cyst growth beneath graft site
Giannini et al. 2009 N = 48 Collagen scaffold + BMA OR Hyaluronic acid membrane scaffold + BMA 17 osteophytectomy, 2 synovectomy, 2 loose body extraction, 1 calcaneal osteotomy 64.4 ± 14.5 6 months 83.3 ± 8.7 12 months 88.9 ± 8.2 18 months 89.7 ± 8.5 24 months 91.4 ± 7.7      2 patients at 12 months showed hypertrophy of new tissue on MRI; at 24 months all patients showed restored focal cartilage layer at defect site on MRI 5 patients evaluated at mean 13 months (12–14); 3 asymptomatic patients with newly formed cartilage 2 symptomatic patients with hypertrophy of new tissue; All patients with smooth, complete and healthy cartilage integration 1 superficial infection at portal
Giannini et al. 2013 N = 20 Collagen scaffold + BMA OR Hyaluronic acid membrane scaffold + BMA None 63.73 ± 14.13 48 (±6) months 82.19 ± 17.04      20 patients under went MRI T2 Mapping: 45 % Complete defect filling 45 % Incomplete >50 % filling 10 % Incomplete <50 % 78 % had hyaline like cartilage at latest follow-up Not performed None Reported