Bone marrow aspirate concentrate for the treatment of osteochondral lesions of the talus: a systematic review of outcomes

Jorge Chahla; Mark E. Cinque; Jason M. Schon; Daniel J. Liechti; Lauren M. Matheny; Robert F. LaPrade; Thomas O. Clanton

doi:10.1186/s40634-016-0069-x

Journal of Experimental Orthopaedics

Table 2 Outcome study reported data metrics

From: Bone marrow aspirate concentrate for the treatment of osteochondral lesions of the talus: a systematic review of outcomes

Study	Study Size	Treatment	Additional Treatment	Preoperative AOFAS	Postoperative AOFAS	Preoperative FAOS	Postoperative FAOS	Preoperative SF-12	Postoperative SF-12	Radiologic findings	Second-look arthroscopy	Complications
Hannon et al. 2016	N = 34	BMS alone Vs BMS with BMAC	None			BMS 54.8 BMS + BMAC 60.6	BMS 68.3 BMS + BMAC 77.6	BMS 38.5 BMS + BMAC 42.5	BMS 55.3 BMS + BMAC 61.9	Total MOCART score BMS: 55.8 BMAC + BMS: 73.0 (BMAC with significantly greater defect filling, border repair integration, and surface tissue repair at 2 year follow-up)	Not performed	BMS: 1 subchondral cyst formation BMAC/BMS: 2 superficial peroneal nerve dysesthesias
Kennedy and Murawski 2011	N = 72	Osteochondral autograft soaked in BMAC with synthetic filler soaked in BMAC	None			52.67	86.2	59.4	88.6	MRI: In 1 ankle, small cyst formation beneath graft site at 28 months	Not performed	3 donor site knee pain, 1 cyst growth beneath graft site
Giannini et al. 2009	N = 48	Collagen scaffold + BMA OR Hyaluronic acid membrane scaffold + BMA	17 osteophytectomy, 2 synovectomy, 2 loose body extraction, 1 calcaneal osteotomy	64.4 ± 14.5	6 months 83.3 ± 8.7 12 months 88.9 ± 8.2 18 months 89.7 ± 8.5 24 months 91.4 ± 7.7					2 patients at 12 months showed hypertrophy of new tissue on MRI; at 24 months all patients showed restored focal cartilage layer at defect site on MRI	5 patients evaluated at mean 13 months (12–14); 3 asymptomatic patients with newly formed cartilage 2 symptomatic patients with hypertrophy of new tissue; All patients with smooth, complete and healthy cartilage integration	1 superficial infection at portal
Giannini et al. 2013	N = 20	Collagen scaffold + BMA OR Hyaluronic acid membrane scaffold + BMA	None	63.73 ± 14.13	48 (±6) months 82.19 ± 17.04					20 patients under went MRI T2 Mapping: 45 % Complete defect filling 45 % Incomplete >50 % filling 10 % Incomplete <50 % 78 % had hyaline like cartilage at latest follow-up	Not performed	None Reported

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