Table 2 Outcome study reported data metrics
| Study | Study Size | Treatment | Additional Treatment | Preoperative AOFAS | Postoperative AOFAS | Preoperative FAOS | Postoperative FAOS | Preoperative SF-12 | Postoperative SF-12 | Radiologic findings | Second-look arthroscopy | Complications |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Hannon et al. 2016 | N = 34 |
BMS alone Vs BMS with BMAC | None |
BMS 54.8 BMS + BMAC 60.6 |
BMS 68.3 BMS + BMAC 77.6 |
BMS 38.5 BMS + BMAC 42.5 |
BMS 55.3 BMS + BMAC 61.9 |
Total MOCART score BMS: 55.8 BMAC + BMS: 73.0 (BMAC with significantly greater defect filling, border repair integration, and surface tissue repair at 2 year follow-up) | Not performed |
BMS: 1 subchondral cyst formation BMAC/BMS: 2 superficial peroneal nerve dysesthesias | ||
| Kennedy and Murawski 2011 | N = 72 | Osteochondral autograft soaked in BMAC with synthetic filler soaked in BMAC | None | 52.67 | 86.2 | 59.4 | 88.6 | MRI: In 1 ankle, small cyst formation beneath graft site at 28 months | Not performed | 3 donor site knee pain, 1 cyst growth beneath graft site | ||
| Giannini et al. 2009 | N = 48 |
Collagen scaffold + BMA OR Hyaluronic acid membrane scaffold + BMA | 17 osteophytectomy, 2 synovectomy, 2 loose body extraction, 1 calcaneal osteotomy | 64.4 ± 14.5 |
6 months 83.3 ± 8.7 12 months 88.9 ± 8.2 18 months 89.7 ± 8.5 24 months 91.4 ± 7.7 | 2 patients at 12 months showed hypertrophy of new tissue on MRI; at 24 months all patients showed restored focal cartilage layer at defect site on MRI |
5 patients evaluated at mean 13 months (12–14); 3 asymptomatic patients with newly formed cartilage 2 symptomatic patients with hypertrophy of new tissue; All patients with smooth, complete and healthy cartilage integration | 1 superficial infection at portal | ||||
| Giannini et al. 2013 | N = 20 |
Collagen scaffold + BMA OR Hyaluronic acid membrane scaffold + BMA | None | 63.73 ± 14.13 |
48 (±6) months 82.19 ± 17.04 |
20 patients under went MRI T2 Mapping: 45 % Complete defect filling 45 % Incomplete >50 % filling 10 % Incomplete <50 % 78 % had hyaline like cartilage at latest follow-up | Not performed | None Reported |