Table 1 Patient demographics

Hannon et al. 2016

n = 34

12 BMS

22 BMAC + BMS

BMS: 39 (18–60)

BMAC + BMS: 35 (12–68)

BMS: 77.3 (46–100)

BMAC + BMS: 48.3 (34–82)

Mean area:

BMS: 111.2 mm²

CL (3), PL (2), AM (1), CM (1), PM (5)

BMAC + BMS: 103 mm²

AL (3), CL (7), AM (2), CM (8), PM (2)

None reported

Approx. 60 mL of bone marrow aspirate harvested from ipsilateral iliac crest and concentrated using an Arteriocyte Magellan Autologous Platelet Separator System to obtain approximately 3 mL of BMAC.

Mean talar osteochondral lesion area: BMS:111.2 mm²; BMAC/BMS: 103 mm²

Kennedy and Murawski 2011

n = 72

34.19 (16–85)

28.02 (12–64)

Mean AP size:

11.2 mm (6–20 mm)

Mean medial-lateral size: 10.74 mm (7–20 mm)

49 medial talar dome

(2 AM, 33CM, 14 PM),

23 Lateral talar dome

(6 AL, 9 CM, 8 PL)

None reported

Approx. 60 mL of bone marrow aspirate harvested from anterior ilium of the ipsilateral iliac crest and concentrated using a commercial BMAC centrifuge system to obtain roughly 4 mL of BMAC.

Mean anterior-posterior size: 11.2 mm (6–20 mm), mean medial-lateral size 10.74 mm (7–20 mm)

>6 mm diameter talar osteochondral lesion

Giannini et al. 2009

n = 48

28.5 +/− 9.5

29 (24–35)

Mean size: 2.07 +/− 0.48 cm²,

Mean depth 4.0 +/− 0.9 mm; 39 Medial talar dome

9 Lateral talar dome

8 microfracture

5 debridement

2 autologous chondrocyte implantation

60 mL of bone marrow harvested from the posterior iliac crest and concentrated with a Harvest Tech Smart PReP using the Harvest BMAC kit to obtain 6 mL of BMC.

Chronic type II (>1.5 cm², <5 mm deep), mean size 2.07 +/− 0.48 cm², mean depth 4.0 +/− 0.9 mm

Giannini et al. 2013

N = 20

Not Reported

36

MFC (14), LFC (4),

None Reported

60 mL of bone marrow harvested from the posterior iliac crest and concentrated with a Harvest Tech Smart PReP using the Harvest BMAC kit to obtain 6 mL of BMC.

Post-traumatic grade III. IV osteochondral lesions