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Table 1 Patient demographics

From: Bone marrow aspirate concentrate for the treatment of osteochondral lesions of the talus: a systematic review of outcomes

Article Study Size Mean Age Mean Follow-up (months) Location and Size Previous Treatment Marrow harvesting and preparation Focal cartilage defect severity
Hannon et al. 2016 n = 34 12 BMS 22 BMAC + BMS BMS: 39 (18–60) BMAC + BMS: 35 (12–68) BMS: 77.3 (46–100) BMAC + BMS: 48.3 (34–82) Mean area: BMS: 111.2 mm2 CL (3), PL (2), AM (1), CM (1), PM (5) BMAC + BMS: 103 mm2 AL (3), CL (7), AM (2), CM (8), PM (2) None reported Approx. 60 mL of bone marrow aspirate harvested from ipsilateral iliac crest and concentrated using an Arteriocyte Magellan Autologous Platelet Separator System to obtain approximately 3 mL of BMAC. Mean talar osteochondral lesion area: BMS:111.2 mm2; BMAC/BMS: 103 mm2
Kennedy and Murawski 2011 n = 72 34.19 (16–85) 28.02 (12–64) Mean AP size: 11.2 mm (6–20 mm) Mean medial-lateral size: 10.74 mm (7–20 mm) 49 medial talar dome (2 AM, 33CM, 14 PM), 23 Lateral talar dome (6 AL, 9 CM, 8 PL) None reported Approx. 60 mL of bone marrow aspirate harvested from anterior ilium of the ipsilateral iliac crest and concentrated using a commercial BMAC centrifuge system to obtain roughly 4 mL of BMAC. Mean anterior-posterior size: 11.2 mm (6–20 mm), mean medial-lateral size 10.74 mm (7–20 mm) >6 mm diameter talar osteochondral lesion
Giannini et al. 2009 n = 48 28.5 +/− 9.5 29 (24–35) Mean size: 2.07 +/− 0.48 cm2, Mean depth 4.0 +/− 0.9 mm; 39 Medial talar dome 9 Lateral talar dome 8 microfracture 5 debridement 2 autologous chondrocyte implantation 60 mL of bone marrow harvested from the posterior iliac crest and concentrated with a Harvest Tech Smart PReP using the Harvest BMAC kit to obtain 6 mL of BMC. Chronic type II (>1.5 cm2, <5 mm deep), mean size 2.07 +/− 0.48 cm2, mean depth 4.0 +/− 0.9 mm
Giannini et al. 2013 N = 20 Not Reported 36 MFC (14), LFC (4), None Reported 60 mL of bone marrow harvested from the posterior iliac crest and concentrated with a Harvest Tech Smart PReP using the Harvest BMAC kit to obtain 6 mL of BMC. Post-traumatic grade III. IV osteochondral lesions
  1. Abbreviations are as follows: BMAC bone marrow aspirate concentrate, BMS bone marrow stimulation, AL anterolateral, CL centrolateral, PL posterolateral, AM anteromedial, CM centromedial, PM posteromedial