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Table 2 Population and articular cartilage / osteochondral defects characteristics

From: Knee donor-site morbidity after mosaicplasty – a systematic review

First author (year) Population M : F Age (years) Defect location Defect size mean (range) Defect classification Radiological evaluation
Knee
 Atik et al. (2005) n = 12 6 : 6 38 MFC (n = 9) LFC (n = 1) Patella (n = 2) >1 cm diameter Outerbridge Grade IV Arthroscopy
 Espregueira-Mendes et al. (2012) n = 31 22 : 9 30.1 MFC (n = 22) LFC (n = 7) Trochlea (n = 1) Patella (n = 1) 3.3 cm2 ICRS Grade IV MRI
 Gudas et al. (2005) n = 28 19 : 10 24.6 MFC (n = 25) LFC (n = 3) 2.8 cm2 ICRS OCD (n = 13) Full-thickness (n = 15) MRI Radiography
 Hangody et al. (2008) n = 967 N.R. N.R. Femoral condyle (n = 789) Patella (n = 147) Tibia condyles (n = 31) N.R. Outerbridge Grade III or IV (66 %) Osteochondral defects (33 %) MRI Radiography
 Hangody et al. (2010) n = 303 N.R. N.R. MFC (n = 187) LFC (n = 74) LTC (n = 15) MTC (n = 1) Patella (n = 18) Trochlear (n = 8) 2.8 cm2 (1-5) 1.8 cm2 (1-4) 1.2 cm2 (1-2) 1 cm2 2.4 cm2 (1-3) 2.1 cm2 (1-3.5) Outerbridge Grade III or IV (66 %) Shallow osteochondral lesions (33 %) MRI Radiography
 Jakob et al. (2002) n = 42 34 : 18 34 MFC (n = 10) LFC (n = 5) Patella (n = 1) b 4.9 cm2 (1.5-16) ICRS Grade III (n = 23) Grade IV (n = 29) MRI
 Kock et al. (2010) n = 13 8 : 5 33 MFC (n = 10) LFC (n = 3) N.R. Full-thickness cartilage lesions Bone scintigraphy
 Koulalis et al. (2004) n = 18 12 : 6 36 MFC (n = 13) LFC (n = 2) Patella (n = 3) Trochlear (n = 1) 2.5 cm2 Outerbridge Grade IV MRI Radiography
 Quarch et al. (2014) n = 16 N.R. 39.7 MFC (n = 12) LFC (n = 1) Patella (n = 3) 4.6 cm2 Grade I-IV MRI
 Reverte-Vinaixa et al. (2013) n = 17 12 : 5 35 MFC (n = 3) LFC (n = 14) 3.4 cm2 (1-4) Outerbridge Grade III/IV MRI
 Clavé et al. (2016) n = 25 20 : 5 28.3 Femoral condyle (n = 25) 3.5 cm2 ICRS Grade I (n = 1) Grade III (n = 2) Grade IV (n = 22) MRI
Ankle
 Ahmad and Jones (2015) n = 20 11 : 9 41.3 Anteromedial (n = 2) Anterocentral (n = 1) Anterolateral (n = 3) Centromedial (n = 7) Central direct (n = 1) Centrolateral (n = 2) Posteromedial (n = 4) 1.6 cm2 (0.7-2.4) N.R. CT MRI Radiography
 Al-Shaikh et al. (2002) n = 19 6 : 13 32 Medial dome (n = 15) Lateral dome (n = 3) Both (n = 1) 1.2 cm2 (0.5-4) Berndt/Hardy classification Grade I (n = 4) Grade II (n = 6) Grade III (n = 2) Grade IV (n = 7) MRI Radiography
 Baltzer and Arnold (2005) n = 43 30 : 13 31.2 Medial (n = 27) Lateral (n = 14) Central (n = 2) 1.7 cm2 (up to 3.7 cm2) Outerbridge Grade III or IV MRI Radiography
 Gautier et al. (2002) n = 11 8 : 3 31.9 Medial (n = 10) Lateral (n = 1) 1.8 cm2 (0.7-4.2) Berndt and Harty Grade II-IV CT MRI Radiography
 Hangody (2001) n = 36 N.R. 27 N.R. 1 cm2 Berndt and Harty classification Grade III Grade IV CT MRI Radiography
 Kim et al. (2012) n = 48 34 : 18 48.2 Anteromedial (n = 8) Centrolateral (n = 15) Posteromedial (n = 29) 1.5 cm2 (0.5-2.9) N.R. MRI Radiography
 Lee et al. (2003) n = 17 16 : 1 22.7 Medial (n = 16) Lateral (n = 2) 1.0 cm2 (0.6-4) Berndt and Harty Grade III-IV Arthroscopy CT MRI Radiography
 de l’Escalopier et al. (2015) n = 37 29 : 8 33 Medial (n = 12) Posteromedial (n = 14) Lateral (n = 11) 0.85 cm2 (0.4-2.12) N.R. CT MRI Radiography
 Reddy et al. (2007) n = 11 5 : 6 29 Medial (n = 8) Posteromedial (n = 1) Central (n = 1) Anterocentral (n = 1) 1.3 cm2 Full thickness defects MRI Radiography
 Valderrabano et al. (2009) n = 12a 8 : 4a 43a Medial (n = 7) Lateral (n = 14) 1.4 cm2 (0.5-3.6) Berndt/Harty classificationa Grade IV (n = 9) Grade V (n = 5) MRI SPECT-CT
  1. Legend: MFC Medial femoral condyle, LFC Lateral femoral condyle, LTC Lateral tibial condyle, MTC Medial tibial condyle, N.R. Not reported, ICRS International Cartilage Repair Society score, OCD Osteochondritis dissecans, MRI Magnetic resonance imaging, CT Computed tomography, SPECT-CT Single-photon emission computed tomography
  2. a Report of the 12 included patients on the follow-up, from a cohort of 21 patients; b Results reported from the patients with osteochondritis dissecans and localized degeneration; the other articular cartilage lesions came from other reasons, such as, acute trauma or femoropatellar arthrosis