Table 7 Application of hydrogels as cell/drug delivery carriers for OA therapy

HA

injection of autologous MSCs in goat knee joints

(Murphy et al. 2003)

PlnD1-HA microgel

injection of PlnD1-HA to potentiate BMP-2 activity in an experimental murine OA model

(Srinivasan et al. 2012)

Alginate-chitosan beads

injection of beads to reduce OA in rabbits

(Oprenyeszk et al. 2013)

Kartogenin-conjugated chitosan hydrogel

intra-articular delivery to protect against OA in rats

(Kang et al. 2014)

Fibrin/HA-MA hydrogel

induction of bone marrow-derived MSCs chondrogenesis

(Snyder et al. 2014)

Gelatin hydrogels incorporating rapamycine micelles

intra-articular administration to protect against OA in mice

(Matsuzaki et al. 2014)

CM-SIN and GelMA hydrogels

intra-articular injection to reduce OA in mice

(Chen et al. 2016)