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Table 6 Stem cells for OA treatment: clinical evidence from randomized controlled trials

From: Basic science of osteoarthritis

Treatment Procedure Patients Follow-up Outcomes References
BMSCs i.a. 15
(versus HA)
1 year improved function,
higher cartilage quality (MRI)
Vega et al. 2015
BMSCs (HA) i.a.
(meniscectomy)
18
(low versus high MSCs dose versus HA)
2 years pain improvement,
meniscus regeneration (MRI)
Vangsness et al. 2014
BMSCs
(HA)
i.a.
(osteotomy and microfracture)
28
(versus HA)
2 years clinical improvements,
higher cartilage quality (MRI)
Wong et al. 2013
BMCs
(matrix/PEMF)
surgical delivery
(collagen matrix)
15
(versus matrix)
1 year improved recovery Cadossi et al. 2014
PBSCs
(HA)
i.a.
(drilling)
25
(versus HA)
2 years improved cartilage quality (MRI) Saw et al. 2013
ASVF surgical delivery
(microfracture)
40
(versus microfracture)
2 years clinical improvements,
higher cartilage quality (MRI)
Koh et al. 2016
ASVF
(PRP)
i.a.
(osteotomy)
21
(versus PRP)
2 years clinical improvements,
fibrocartilage coverage
Koh et al. 2014
  1. Abbreviations: MSCs mesenchymal stem cells, BMSCs bone marrow-derived MSCs, HA hyaluronic acid, BMCs bone marrow concentrates, PEMF pulsed electromagnetic field, PBSCs peripheral blood stem cells, ASVF adipose stromal vascular fraction, PRP platelet-rich plasma, i.a. intra-articular