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Fig. 4 | Journal of Experimental Orthopaedics

Fig. 4

From: Sustained delivery of recombinant human bone morphogenetic protein-2 from perlecan domain I - functionalized electrospun poly (ε-caprolactone) scaffolds for bone regeneration

Fig. 4

PInDI-PCL scaffold preserved rhBMP-2 bioactivity. a ALP activity of W20–17 cultures exposed to rhBMP-2 released from either PlnD1-conjugated or unmodified PCL scaffolds. Fresh W20–17 cultures were used for each time-point. ALP activity was normalized to DNA content and expressed as a fold-change over basal ALP activity. b Amount of bioactive rhBMP-2 released from PlnD1-modified or unmodified PCL scaffolds as measured by comparing against a rhBMP-2 dose response curve generated by adding rhBMP-2 directly to W20–17 cultures (positive control). (n = 5) Error bars correspond to standard deviation. (*) indicates a statistical difference between groups (p < 0.05)

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