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Table 1 Spearman rank order correlations related to the operated limb at experimental end-point between various biologically relevant clinical and end-point measures (p < 0.05), at either 0 or 20 weeks, or the difference in operated limb over time, or between operated and control hind limb

From: Functional outcome measures in a surgical model of hip osteoarthritis in dogs

Clinical factor

Clinical or end-point factor

ρ

Change in bodyweight 0–20 weeks

Operated total joint & femoral head Mankin score

−0.82– −0.79

Change in bodyweight 0–20 weeks

Range of motion operated limb at 20 weeks

0.89

Range of motion operated limb at 20 weeks

Operated total joint and femoral head Mankin score

−0.96– −0.93

Range of motion operated limb at 20 weeks

Maximum peak pressure, force and impulse O:C at 20 weeks

0.82–0.89

Range of motion operated limb at 20 weeks

Impulse O:C 20 weeks

0.82

Difference in range of motion between operated and control 20 weeks

Operated acetabulum Mankin score

−0.93

Difference in range of motion between operated and control 20 weeks

Bodyweight distribution to operated limb at 20 weeks

0.89

Limb circumference operated limb

Operated mean synovial score

−0.86

Limb circumference operated limb

Control mean synovial score

0.79

CBPI 20 weeks

Bodyweight distribution change hind limbs 0–20 weeks

−0.77

CBPI 20 weeks

Bodyweight distribution change forelimbs 0–20 weeks

0.77

CBPI 20 weeks

Bodyweight distribution to operated limb at 20 weeks

−0.85

Bodyweight distribution to operated limb at 20 weeks

Operated acetabulum Mankin score

−0.82

Bodyweight distribution change operated 0–20 weeks

Operated mean synovial score

−0.93

Bodyweight distribution to operated limb at 20 weeks

Control limb acetabulum Mankin score zone 2,6

0.79–0.90

Bodyweight distribution to operated limb at 20 weeks

Bodyweight distribution to operated limb at 0 weeks

0.86

Bodyweight distribution change operated 0–20 weeks

Impulse O:C at 20 weeks

0.79

Maximum force O:C 20 weeks

Operated total joint and femoral head Mankin score

−0.86– −0.79

Maximum force O:C 20 weeks

Control femoral head Mankin score

−0.83

Maximum force O:C 20 weeks

Impulse O:C 20 weeks

0.96

Maximum peak pressure O:C 20 weeks

Operated total joint and femoral head Mankin score

−0.96– −0.93

Radiographic score operated 20 weeks

Operated mean synovial and total joint Mankin score

0.77–0.79

Compression index operated 20 weeks

Operated mean synovial score

0.82

Compression index operated 20 weeks

Distraction index operated 20 weeks

0.86

Compression index operated 20 weeks

Radiographic score operated 20 weeks

0.77

Compression index operated 20 weeks

Mean number night activity bouts 20 weeks

−0.79

Distraction index operated 20 weeks

Radiographic score operated 0 weeks

0.94

  1. Notes: CBPI canine brief pain inventory, O:C operated vs. control