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Table 1 Effects of IFP-conditioned media on gene expression in patient-matched chondrocytes and synoviocytes

From: New trends in articular cartilage repair

Genes

Chondrocytes

Synoviocytes

iNOS

427.22 ± 123.76*

2.63 ± 0.45*

COX-2

57.39 ± 12.85*

362.75 ± 145*

mPGES-1

41.25 ± 7.51*

13.64 ± 1.82*

MMP13

18.29 ± 2.96*

ND

ADAMTS-4

86.64 ± 21.13*

ND

IGF-I

8.86 ± 2.04*

4.60 ± 2.64

TGF-β1

1.49 ± 0.28

1.09 ± 0.16

Type-II collagen

1.43 ± 0.19

ND

Aggrecan

1.27 ± 0.18

ND

  1. The expression of inflammatory genes (iNOS, mPGES-1, COX-2) and of genes coding for matrix components (type-II collagen, aggrecan) or for factors involved in cartilage remodelling (MMP13, ADAMTS-4, IGF-I, TGF-β1) was analyzed in patient-matched cells (n = 20) by real-time quantitative PCR after 24 h of culture in paired conditioned medium. Data are expressed as means ± SEM of the mean over control values. *P ≤ 0.05 between IFP conditioned media-treated and control cells.