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Table 1 Effects of IFP-conditioned media on gene expression in patient-matched chondrocytes and synoviocytes

From: New trends in articular cartilage repair

Genes Chondrocytes Synoviocytes
iNOS 427.22 ± 123.76* 2.63 ± 0.45*
COX-2 57.39 ± 12.85* 362.75 ± 145*
mPGES-1 41.25 ± 7.51* 13.64 ± 1.82*
MMP13 18.29 ± 2.96* ND
ADAMTS-4 86.64 ± 21.13* ND
IGF-I 8.86 ± 2.04* 4.60 ± 2.64
TGF-β1 1.49 ± 0.28 1.09 ± 0.16
Type-II collagen 1.43 ± 0.19 ND
Aggrecan 1.27 ± 0.18 ND
  1. The expression of inflammatory genes (iNOS, mPGES-1, COX-2) and of genes coding for matrix components (type-II collagen, aggrecan) or for factors involved in cartilage remodelling (MMP13, ADAMTS-4, IGF-I, TGF-β1) was analyzed in patient-matched cells (n = 20) by real-time quantitative PCR after 24 h of culture in paired conditioned medium. Data are expressed as means ± SEM of the mean over control values. *P ≤ 0.05 between IFP conditioned media-treated and control cells.