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Table 2 Comparison of surgical anatomical parameters for HTO in sheep and humans (adapted from (Pape & Madry 2013) with permission)

From: Large animal models in experimental knee sports surgery: focus on clinical translation

Congenital anatomical differences

Sheep stifle joint

Human knee

Surgical consequence for the sheep HTO model

Tibial plateau width [mm]

46-56

60-70

Match screw length

   

Narrow and strait plate design necessary

Tibia valga [°]

3.5

0

Valgus overcorrection more likely

Normal knee range of motion (transverse axis) [°]

0-35-72

0-0-140

Dorsal plate positioning after open wedge HTO is recommended due to increased loading of the posterior tibial plateau

tibial tuberosity dimension adding to the AP diameter of the tibial head [%]

30-35

10-15

Anterior plate misplacement more likely

Tibial tuberosity height distance in relation to joint line [mm]

10-15 mm

25-30 mm

Anterior plate misplacement more likely

Posterior slope of the posterior articular surface [°]

20 ± 3

0-10

Narrow and straight plate design necessary for posterior placement

Biomechanical properties of tibial head

Brittle cortical bone, together with little spongious bone

Elastic cortical bone with an exuberant amount of spongious bone

Bicortical proximal screw placement mandatory to avoid fracture/dislocation

Biplanar osteotomy mandatory regardless of the desired direction of correction

Musculature of the hind limb

Voluminous on medial and lateral side of the femur

Remote from bony knee structures

Distal femoral and proximal lateral tibial osteotomy almost impossible to conduct, stay on the medial side of the proximal tibia for any desired correction angle

Trochlea ridge

Medial ridge extending further cranially and dorsally than lateral ridge

Lateral ridge extending further laterally and anteriorly

Higher propensity of patella instability after valgus correction