IN VITRO EVIDENCE | ||
---|---|---|
PRP EFFECTS ON… | - Increase chondrocyte proliferation rate | |
- Stimulate chondrocyte phenotype expression and mainteinance | ||
- Increase matrix molecules production | ||
- Overall reduction of inflammatory response | ||
- Promotion of MSCs proliferation, adhesion and migration | ||
- Increased expression of Collagen II | ||
- Anti or pro-flogistic effects demonstrated, according to the particular PRP formulation used | ||
- Increase in meniscal cell proliferation rate | ||
- Stimulation of GAG synthesis | ||
- Stimulation of migration and chondrogenic differentiation of cortico-spongious bone cells | ||
- Superior chondrogenic differentiation of BMSCs | ||
- Enhanced proliferation rate and retained chondrogenic differentiation potential of ADMSCs | ||
- Increase in proliferation and migration induction of peripheral blood and umbilical cord blood MSCs | ||
Bacterial culture [ 40 ] | - PRP is able to provide an early protection against bacterial contamination due to the release of antimicrobial proteins | |
ANIMAL MODELS | ||
PRP EFFECTS ON… | Rats [ 31 ] | - In chondral lesion model: PRP improves tissue healing and collagen II expression |
- In OA model: controversial results regarding chondroprotective effects | ||
- In Osteochondral lesion: no macroscopic, microscopic and biomechanical benefit after PRP administration | ||
- In OA model: positive influence on cartilage degeneration process (especially in moderate OA) | ||
Sheep [ 35 ] | - In chondral lesion model: improvement in macroscopic, histologic, and biomechanical cartilage scores. Beneficial effects also when applied together with microfractures | |
Pig [ 37 ] | - In Rheumatoid Arthritis model: overall reduction in pro-flogistic enzymes and molecules; chondroprotective effect | |
Horse [ 34 ] | - In OA model: positive modulation of joint homeostasis, with reduction of lameness and joint effusion up to middle term evaluation |